Diabetes Research
Membrane proteins are the most successful class of therapeutic targets. Creative Biolabs has developed a comprehensive collection of membrane protein in vitro assays for drug discovery that cover most membrane protein targets.
Creative Biolabs has the assays you can rely on for high throughput screening, lead optimization, characterizing and discovering targets, and uncovering the complexity of disease pathways. We can offer membrane protein in vitro assay kits that save valuable laboratory time and is ideal for high throughput screening.
Membrane protein stable cell lines are widely used in many areas of biomedical research. Creative Biolabs can offer membrane protein stable cell lines to stablish in vitro models for High Throughput Screening.
Creative Biolabs' membrane preparations are useful for membrane protein research. We offer membrane preparations to study the role of membrane proteins in diseases. Membrane preparations from Creative Biolabs are quality-assured frozen membranes from cells expressing recombinant or natural receptors.
Creative Biolabs offers high-quality, innovative tools to help research groups accelerate membrane protein drug discovery. They can be found by targets. If there is no product that meets your needs, please contact us.
Diabetes is a condition in which the body either can't produce insulin or can't properly use the insulin it produces. Insulin is necessary for the body to be able to use sugar for energy. diabetes can lead to serious health problems, including heart disease, stroke, kidney disease, blindness, and amputation of limbs. diabetes research is essential in order to develop new treatments and find a cure for this potentially devastating condition. scientists are constantly working to expand our understanding of diabetes and its causes, as well as to develop more effective treatments. In recent years, there have been significant strides made in diabetes research, and there is hope that a cure will be found in the not-too-distant future.
Fig.1 Pharmacologic targeting of numerous organ system for the treatment of diabetes. (Leslie, et al., 2021)
Type-I Diabetes
Though type-I diabetes was once considered a childhood disease, recent research shows that type-I diabetes can occur at any age. While the exact cause of type-I diabetes is still unknown, researchers believe that it is caused by a combination of genetic and environmental factors. In type-I diabetes, the body's immune system attacks and destroys the insulin-producing cells in the pancreas. As a result, people with type-I diabetes must take insulin injections every day in order to control their blood sugar levels. Though there is no cure for type-I diabetes, researchers are working hard to develop new treatments and find a cure.
Type-II Diabetes
Type-II diabetes, also known as adult-onset diabetes, is the most common type of diabetes, and its incidence is on the rise. While type-II diabetes can be controlled through diet and exercise, in many cases it requires lifelong treatment with insulin injections. There is currently no cure for type-II diabetes, but researchers are working tirelessly to find one. In recent years, there have been significant advancements in type-II diabetes research, and scientists are hopeful that a cure will be found in the near future.
Membrane Proteins in Diabetes Research
In recent years, much of the research into diabetes has focused on the role of membrane proteins. These proteins play a key role in insulin signaling, and defects in their function are thought to contribute to diabetes. By understanding how these proteins work, scientists hope to develop more effective treatments for diabetes. In the meantime, patients can Control diabetes by maintaining a healthy lifestyle and monitoring their blood sugar levels carefully. With proper treatment, diabetes need not be a life-threatening condition.
- Insulin Receptors
The insulin receptor is a membrane protein that plays a key role in insulin signaling. Targeting insulin receptors with drugs is one potential treatment for diabetes. Insulin receptor inhibitors are drugs that block the insulin receptor and prevent insulin from binding to it. This can help to improve insulin signaling and lower blood sugar levels. There are also drugs that mimic insulin and bind to the insulin receptor. These drugs can help to stimulate insulin signaling and lower blood sugar levels. There is still much research to be done in this area but targeting insulin receptors holds promise as a treatment for diabetes.
Fig.2 A diagram of insulin signaling pathway. (Matthew, 2004)
- GLUT4
GLUT4 is found in the cells of the body that are responsible for regulating blood sugar levels. When blood sugar levels rise, GLUT4 helps to transport sugar into the cells so that it can be used for energy. However, in people with diabetes, GLUT4 doesn't work as well as it should. As a result, sugar builds up in the bloodstream, causing health problems. The researchers behind the new study believe that by targeting GLUT4, they may be able to develop new treatments for diabetes that can improve blood sugar control and prevent diabetes-related complications.
Fig.3 Activation of the glucose transporter GLUT4. (Ashish, et al., 2020)
References
- Leslie, S.; et al. New Aspects of Diabetes Research and Therapeutic Development. Pharmacological Reviews. 2021, 73(3): 1001-1015.
- Matthew, J. IRS2 takes center stage in the development of type 2 diabetes. The Journal of Clinical Investigation. 2004, 114(7): 886-888.
- Ashish, C.; et al. Interaction between oxidative stress and diabetes: a mini-review. Journal of Diabetes and Metabolic Disorders. 2020, 7(2): 58-61.
