mProX™ Human SIK2 Stable Cell Line

[CAT#: S01YF-1023-PY83]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX464	Magic™ Human QIK(SNF1LK2) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MGC-803

Target Classification

Kinase Cell Lines

Target Research Area

Diabetes Research

Related Diseases

Brachydactyly, Type C; Type 2 Diabetes Mellitus

Gene ID

Human:23235

UniProt ID

Human:Q9H0K1

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

SIK2, a member of the salt-inducible kinase family, has been implicated in various cancer types, including non-small cell lung cancer (NSCLC), breast cancer, and immune-related diseases. In NSCLC, SIK2 mRNA stability is enhanced by the m(6)A modification mediated by IGF2BP1, promoting cancer progression. SIK2 overexpression in NSCLC cells leads to increased cell proliferation, migration, invasion, and suppression of the Hippo/YAP pathway. In a Drosophila cancer model, SIK2 and SIK3 synergize with Hipk to promote tumorigenesis. SIK2 is highly expressed in epithelial cells of breast cancer and may serve as a potential prognostic and predictive biomarker. Additionally, SIK2 deficiency inhibits lymphocyte maturation and promotes immune injury. Overall, SIK2 plays diverse roles in cancer progression and immune regulation, suggesting its potential as a diagnostic and therapeutic target in various diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Casey Garcia (Verified Customer)

How does SIK2 contribute to the progression of renal cell carcinoma? Sep 20 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

FTO-mediated autophagy promotes the progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability. Sep 20 2020

chat Alex Brown (Verified Customer)

Can SIK2 inhibition enhance PARP inhibitor activity in ovarian and breast cancers? Jul 04 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, SIK2 inhibition synergistically enhances PARP inhibitor activity in ovarian and triple-negative breast cancers. Jul 04 2022

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