mProX™ Human SIK2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 The impact of SIK2 knockdown on AKT/GSK3β/β-catenin signaling, as well as the reduced migratory and invasive capabilities of cells, was entirely counteracted by the complete restoration of SIK2 expression facilitated by pSIK2-mut.
The impact of reintroducing a siRNA-resistant SIK2 construct into the SIK2-knockdown MGC830 cells was assessed concerning alterations in the expression of AKT/GSK3β/β-catenin signaling molecules (left), as well as the modulation of cell migratory and invasive capabilities (middle and right). Evaluation was conducted utilizing a scale bar of 200 µm.
Ref: Dai, Xiao-man, et al. "SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases." Molecular oncology 15.1 (2021): 228-245.
Pubmed: 33128264
DOI: 10.1002/1878-0261.12838
Research Highlights
Xu, Yan. et al. "IGF2BP1 enhances the stability of SIK2 mRNA through m6A modification to promote non-small cell lung cancer progression." Biochemical and biophysical research communications, 2023.
Non-small cell lung cancer (NSCLC) is a well-known public health issue worldwide. Studies have demonstrated that Salt-inducible kinase 2 (SIK2) is expressed differently in different types of cancer and is associated with cancer advancement. However, the specific role of SIK2 in NSCLC has not been fully determined and warrants further exploration. Uncovering the specific function of SIK2 in NSCLC could potentially reveal innovative approaches for targeted treatment.
Xu, Yan. et al. "IGF2BP1 enhances the stability of SIK2 mRNA through m6A modification to promote non-small cell lung cancer progression." Biochemical and biophysical research communications, 2023.
Pubmed:
37866243
DOI:
10.1016/j.bbrc.2023.10.045
Yu, Kewei. et al. "The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model" Frontiers in cell and developmental biology, 2023.
Homeodomain-interacting protein kinases (Hipks) are known to play crucial roles in controlling cell proliferation, apoptosis, and tissue development. Recent studies have revealed that overexpression of Hipk in transgenic mice leads to a significant rise in programmed cell death and abnormal tissue development. These findings suggest that Hipks may have a key role in maintaining tissue homeostasis, and their dysregulation could contribute to the onset of various pathologies. Further research in this area is needed to fully understand the mechanisms behind Hipk-mediated cellular processes.
Yu, Kewei. et al. "The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model" Frontiers in cell and developmental biology, 2023.
Pubmed:
37854071
DOI:
10.3389/fcell.2023.1214539
