NEK3
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon.
| Full Name | NIMA related kinase 3 |
| Gene ID | Human: 4752 Mouse: 23954 Rat: 306576 Monkey: 710127 |
| UniProt ID | Human: P51956 Mouse: Q9R0A5 Rat: D3ZCU1 |
| Alternative Names | HSPK36;serine/threonine-protein kinase Nek3;HSPK 36;NIMA (never in mitosis gene a)-related kinase 3;glycogen synthase A kinase;hydroxyalkyl-protein kinase;never in mitosis A-related kinase 3;nimA-related protein kinase 3;phosphorylase B kinase kinase |
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mProX™ Human NEK3 Stable Cell Line
[CAT#: S01YF-1023-PY25]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;T47D;MDA-MB-231
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