mProX™ Human IGF1R Stable Cell Line

Product Information

Target Protein

IGF1R

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Digestive and Renal Research; Immunology Research; Diabetes Research

Related Diseases

Insulin-Like Growth Factor I and Nk-Cell Enteropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway

Gene ID

3480

UniProt ID

P08069

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Human cells have a protein called the insulin-like growth factor 1 (IGF-1) receptor on their surface. The hormones insulin-like growth factor 1 (IGF-1) and IGF-2, which are related, both activate this transmembrane receptor. It is a member of the broad class of receptors for tyrosine kinase. The polypeptide protein hormone IGF-1, which shares a chemical structure with insulin, is mediated by this receptor. IGF-1 is crucial for growth and still has anabolic effects in adults, which means it can cause target tissues like skeletal muscle to enlarge. Mice deficient in the IGF-1 receptor exhibit a sharp decline in body mass and die late in development. This demonstrates the receptor's potent growth-promoting ability. The customized IGF1R stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I am truly impressed with the performance of this IGF1R KO cell line. Dec 13 2022

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I purchased the IGF1R KO cell line from Creative Biolabs. The provided documentation was comprehensive and helped me optimize my assay conditions. Jul 11 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 IGF-1R expression in xenograft tumors, glioma cell lines, and human glioblastomas.

In U87 tumors, IGF-1R positivity was only partially observed in a few dispersed tumor cells, while most GS-12 cells showed significant staining. On the other hand, vascular immunoreactivity was more noticeable in GS-12 tumors than U87 tumors. Particularly, GS-12 tumors showed little to no staining on fragile capillaries, but U87 tumors' dilated vasculature showed high reactivity.

Ref: Zamykal, Martin, et al. "Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms." Neuro-oncology 17.8 (2015): 1076-1085.

Pubmed: 25543125

DOI: 10.1093/neuonc/nou344

Research Highlights

Based on the expression of hormones and ERRB2 receptors, as well as gene expression profiling, breast tumors are classified into subtypes. IGF1R has a distinct expression pattern and function in each breast cancer subtype, despite the fact that it affects tumorigenic characteristics and treatment resistance in all of them.
Farabaugh, Susan M., David N. Boone, and Adrian V. Lee. "Role of IGF1R in breast cancer subtypes, stemness, and lineage differentiation." Frontiers in endocrinology 6 (2015): 59.
Pubmed: 25964777 DOI: 10.3389/fendo.2015.00059

The structural knowledge of the IR and IGF1R has advanced, and this study explores how these findings can influence the development of small-molecule modulators of the IR-IGF1R hybrid receptors to comprehend their function in cell biology.
Turvey, Samuel J., et al. "Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators." RSC Medicinal Chemistry 13.4 (2022): 360-374.
Pubmed: 35647546 DOI: 10.1039/d1md00300c