mProX™ Human SLC30A8 Stable Cell Line
[CAT#: S01YF-1123-KX132]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Transporter Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
SLC30A8
Target Family
SLC Transporter
Target Protein Species
Human
Host Cell Type
MEL1; CHO-K1; HEK293
Target Classification
Transporter Cell Lines
Target Research Area
Diabetes Research
Related Diseases
Type 2 Diabetes Mellitus; Type 1 Diabetes Mellitus
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The zinc transporter ZnT8 is encoded by SLC30A8. It is expressed in β cells and is in charge of transferring zinc into insulin granules, which is required for the packing and release of insulin. This gene has been linked to β-cell biology, but until GWAS linked the missense variant R325W to T2D, it was unknown that changes in this pathway may cause T2D. Further studies on animals revealed that when glucose or a high-fat diet is presented to mice lacking this gene, there are mild anomalies in the way insulin is secreted. Even in β-cell-specific knockout mice, these abnormalities are evident, and they can be attributed to function loss brought on by the risk R325 gene. However, an examination of the protein's crystal structure suggests that the suggested change of an amino acid may not have a significant impact on function. The customized SLC30A8 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Christopher
The SLC30A8 cell line worked flawlessly, and the detailed protocols provided by the company made the whole process much easier.
Mar 13 2022
Verified Customer
Carol
The mouse SLC30A8 overexpression cell line was delivered promptly, and it performed exceptionally well in my assays.
May 04 2020
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
