Recommended
In Vitro Cellular Assays
Membrane Protein Stable Cell Lines
Membranes and Lysates
Staining and Imaging Reagents
Membrane Protein Virus Particles
Cells use membrane proteins to transduce signals into cells, transport ions and molecules, bind the cell to a surface or substrate, and catalyze reactions. The majority of therapeutic targets are membrane proteins. To advance the success of your projects, we offer a wide range of in vitro cellular assays to evaluate the therapeutic effects of your candidate against the membrane protein targets.
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Membrane proteins are prime drug targets due to their essential role in regulating physiological processes. Numerous human diseases are associated with aberrant membrane protein functions. Our experienced technicians and isolation techniques ensure you receive the highest quality membrane protein stable cell lines for membrane protein functional studies, membrane protein drug screening, etc.
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Methods for cell disruption are host dependent and essentially the same protocols are used for recovery of membrane proteins as for water-soluble proteins. Cell disruption yields a membrane fragments/vesicles suspension containing the membrane proteins and other material as contaminants. Depending on the purification technique employed, these contaminants will be removed.
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Membrane dyes are commonly employed in a range of cell types to label membranes. In solution, the dyes are weakly fluorescent, but in lipid bilayers, they become very visible. The dyes are suitable for long-term cell labeling and tracking research because they are high stable, low toxicity and very little dye transfer in between cells. The dyes are internalized by endocytosis when live cells are cultured after staining.
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Membrane protein virus particles display highly-expressed copies of membrane proteins in their native conformation, providing an alternative to membrane protein stable cell lines, membrane preparations, detergent-solubilized proteins and other membrane protein preparation strategies. Membrane protein virus particles can be used for a wide range of applications in antibody production, antibody discovery, binding assays and functional assays.
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Science Driven, Customer Focused
We offer custom membrane protein stable cell line services to overexpress or knockdown/knockout the target protein according to your requirements.
We are proud to offer our clients a series of GPCR drug discovery services with the best quality and most competitive price.
Our virtual drug screening can reduce the size of chemical library, raise the possibility of finding innovative hits, and mitigate the risk of failure in the lead optimization process.
Membrane proteins are prime drug targets due to their essential role in regulating physiological processes.
DNA Encoded Library Screening is an affinity selection process.
G Protein-Coupled Receptors (GPCRs) are the focus of new advances in drug discovery. GPCRs initiate many different cellular processes and their cell surface location makes them easily accessible to a variety of drug-like molecules.
Creative Biolabs is a contract research organization that provides drug discovery services and products to pharma and biotech companies worldwide. We have supported membrane protein research for more than 10 years. Creative Biolabs offers a broad range of products to support your in-house drug discovery projects through our products brand of DiscoverMP. In addition to high quality products, our excellent scientists work together to understand your specific requirements and identify the right solution for your program. We are ready to be your partner at every step. Your success is our mission.
