NR1I3
This gene, which is a major regulator of xenobiotic and endobiotic metabolism, encodes a member of the nuclear receptor superfamily. The protein regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as members of the cytochrome P450 family, by binding to DNA as a monomer or heterodimer with the retinoid X receptor. Contrary to other nuclear receptors, this transcriptional regulator is controlled by both agonists and inverse agonists despite being constitutively active in the absence of ligand. This protein is moved to the nucleus upon ligand interaction, where it either activates or represses transcription of the target gene. Bilirubin, many foreign substances, steroid hormones, and prescription medications are some of these ligands.
| Full Name | Nuclear receptor subfamily 1 group I member 3 |
| Gene ID | Human: 9970 Mouse: 12355 Rat: 65035 Monkey: 574249 |
| UniProt ID | Human: Q14994 Mouse: O35627 Rat: Q9QUS1 Monkey: Q8MIM3 |
| Alternative Names | CAR; CAR1; MB67; nuclear receptor subfamily 1 group I member 3; constitutive activator of retinoid response; constitutive active receptor; constitutive active response; constitutive androstane receptor; orphan nuclear hormone receptor; orphan nuclear receptor MB67 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NR1I3 Target Family: Vitamin D Receptor Target Protein Species: Human Host Cell Type: Hap1; CHO-K1; HEK293
