mProX™ Human PPARG Stable Cell Line

[CAT#: S01YF-1123-KX105]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Nuclear Receptor

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

PPARG

Target Family

Peroxisome Proliferator-activated Receptor

Target Protein Species

Human

Host Cell Type

HepG2; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Diabetes Research; Metabolic Research

Related Diseases

Lipodystrophy

Gene ID

5468

UniProt ID

P37231

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Encoded by the PPARG gene in humans, peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG) is a type II nuclear receptor that functions as a transcription factor. PPARG controls the metabolism of glucose and the storage of fatty acids. PPARG-activated genes promote fat cells' adipogenesis and lipid absorption. PPARG is a master regulator of adipocyte development, as demonstrated by the absence of adipose tissue in PPARG knockout mice. PPARG improves fatty acid storage in fat cells (lowering lipotoxicity), promotes adiponectin release from fat cells, induces FGF21, and upregulates the CD38 enzyme to boost nicotinic acid adenine dinucleotide phosphate synthesis. All of these mechanisms increase insulin sensitivity. The customized PPARG stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Sarah

The PPARG overexpression cell line has not disappointed. It consistently delivers accurate results, making my work much more impactful. Mar 22 2021

chat Verified Customer

chat Dorothy

The protocol of human PPARG cell line was straightforward, and the results were consistent. Sep 07 2022

chat Verified Customer

FAQ

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