mProX™ Human INSR Stable Cell Line

Product Information

Target Protein

INSR

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Diabetes Research

Related Diseases

Donohue Syndrome and Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities. Among its related pathways are GPCR Pathway and ERK Signaling

Gene ID

3643

UniProt ID

P06213

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The INSR gene codes for the production of an insulin receptor protein, which is present in a variety of cell types. Insulin receptors bind to the insulin hormone that circulates in the bloodstream and are implanted in the outer membrane of the cell. When the insulin receptor is first made, it is a single, lengthy protein that needs to be divided into two alpha and two beta subunits in order to be processed. Together, these subunits form a functional receptor. While the beta subunits stay inside the cell, the alpha subunits protrude from the cell's surface. When the alpha subunits bind to insulin, the beta subunits initiate cellular signaling pathways that affect a variety of cellular processes. The customized INSR stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Brian

I recently had the opportunity to try the INSR KD cell line from Creative Biolabs, and I am quite impressed. Apr 09 2022

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chat Sharon

I can't speak highly enough about the human INSR cell line. It has exceeded my expectations in terms of performance. Mar 10 2020

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FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 Expression of the insulin receptor (INSR) on human myeloma cell lines.

Pearson's correlation analyses were conducted to examine the relationships between the expression of the INSR gene, as measured by real-time reverse transcriptase-PCR (RT-PCR), and the Affymetrix probe set 226450_at, as well as the INSR detection using FACS analysis. GAPDH was utilized to standardize real-time RT-PCR results, and XG-6 HMCL was employed as a reference.

Ref: Sprynski, Anne Catherine, et al. "Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation." Leukemia 24.11 (2010): 1940-1950.

Pubmed: 20844560

DOI: 10.1038/leu.2010.192

Research Highlights

For those in China covered by various health insurance schemes, financial protection and unequal access to healthcare are significantly impacted by the fragmentation of social health insurance systems.
Meng, Qingyue, et al. "Consolidating the social health insurance schemes in China: towards an equitable and efficient health system." The Lancet 386.10002 (2015): 1484-1492.
Pubmed: 26466052 DOI: 10.1016/S0140-6736(15)00342-6