FFAR3
Short chain fatty acids (SCFAs), a key byproduct of dietary fiber digestion, activate this G protein-coupled receptor, which controls intestinal immunity as well as the body's overall energy homeostasis. The gut microbiota of omnivorous mammals, which breaks down dietary fibers, is principally responsible for producing the short chain fatty acids acetate, propionate, and butyrate. SCFAs function as both energy producers and signaling molecules. That G protein-coupled receptor is most likely connected to the G(i/o)-alpha family of G proteins, which are pertussis toxin-sensitive. When it is activated, inositol 1,4,5-trisphosphate is produced, intracellular calcium is mobilized, the MAPK3/ERK1 and MAPK1/ERK2 kinases are phosphorylated, and intracellular cAMP buildup is inhibited.
| Full Name | Free fatty acid receptor 3 |
| Gene ID | Human: 2865 Mouse: 233080 Rat: 365228 Monkey: 708732 |
| UniProt ID | Human: O14843 Mouse: Q3UFD7 Rat: B2GV46 |
| Alternative Names | FFA3R; GPR41; GPR42; G-protein coupled receptor 41; FFAR3; Free fatty acid receptor 3 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Gα16 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Gαqi5 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Target Protein Species: Mouse Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Gα16 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Receptors Target Protein Species: Human
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Target Protein Species: Rat Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR3 Target Family: Free Fatty Acid Family Target Protein Species: Human Host Cell Type: NCM460;CHO-K1;HEK293
