INSR
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
| Full Name | insulin receptor |
| Gene ID | Human: 3643 Mouse: 16337 Rat: 24954 Monkey: 706009 |
| UniProt ID | Human: P06213 Mouse: P15208 Rat: P15127 |
| Alternative Names | HHF5; CD220;insulin receptor;IR |
Product List
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Magic™ Human INSR CHO-K1 Cell Line
[CAT#: S01YF-0123-KX283]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: INSR Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
mProX™ Human INSR Stable Cell Line
[CAT#: S01YF-1123-KX266]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: INSR Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
mProX™ Human INSRR Stable Cell Line
[CAT#: S01YF-1123-KX269]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: INSRR Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
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