mProX™ Human GCK Stable Cell Line

[CAT#: S01YF-1123-KX248]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Lot Number

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1153	Magic™ Human GCK in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

GCK

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Diabetes Research; Reproductive Research

Related Diseases

Hyperinsulinemic Hypoglycemia, Familial, 3 and Maturity-Onset Diabetes Of The Young, Type 2. Among its related pathways are glycolysis (BioCyc) and trehalose degradation

Gene ID

2645

UniProt ID

P35557

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The GCK gene codes for the production of the glucokinase protein. This protein is crucial to the body's process of breaking down carbohydrates. The liver and the pancreatic beta cells contain the majority of the enzyme glucosekinase. The hormone insulin, which is produced and released by beta cells, helps control blood glucose levels by limiting the amount of glucose that enters cells from the bloodstream and is used as fuel. As a sensor, glucose kinase detects an increase in blood glucose levels and aids in triggering the release of insulin from beta cells to regulate them. Glucokinase in the liver assists in determining when more glucose should be ingested and transformed into glycogen, a significant source of energy that is stored in the body. The customized GCK stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ashley

This is indeed a powerful GCK cell line. Jan 08 2020

chat Verified Customer

chat Jason

I can use the GCK cell line to direct measurement when testing complex biological samples. Jun 29 2020

chat Verified Customer

FAQ

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