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  • mProX™ Human KCNJ11 Stable Cell Line

    [CAT#: S01YF-1123-KX45]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Protein
    KCNJ11
    Target Family
    KATP
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Diabetes Research
    Related Diseases
    Hyperinsulinemic Hypoglycemia; Diabetes Mellitus
    Gene ID
    UniProt ID

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The ATP-sensitive potassium (K-ATP) channel's subunits are made according to instructions provided by the KCNJ11 gene. K-ATP channels are made up of eight subunits each. The KCNJ11 gene produces four subunits, while the ABCC8 gene produces four more subunits. Beta cells are the pancreatic cells that secrete the hormone insulin, and they contain K-ATP channels. The amount of glucose in the bloodstream causes the K-ATP channels, which are embedded in cell membranes, to open and close. Simple sugar glucose serves as the body's main source of energy for the majority of its cells. When glucose levels rise, the K-ATP channels close, causing beta cells to release more insulin into the bloodstream and assisting in blood glucose regulation. The customized KCNJ11 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    chat Lisa

    I purchased the cell line and it work well for my research. Mar 02 2021

    chat Verified Customer

    chat Jason

    I was so pleased with the cell line I received from this business. Oct 11 2021

    chat Verified Customer

    FAQ

    Any questions about our products? Please visit our frequently asked questions page.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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