Membrane Protein Drug Discovery In Vitro Assays
Membrane proteins are the most successful class of therapeutic targets because they regulate a wide range of physiological functions. More than 60% of all FDA-approved small-molecule therapeutic targets are membrane proteins. As the biggest cell-surface receptors, the G-protein coupled receptor (GPCR) superfamily is the target of 34% of all therapeutic medications. However, the scarcity of screening resources is a major issue that both drug discovery centers and small laboratories face. Therefore, Creative Biolabs develops cost-effective, widely applicable in vitro assays for membrane protein drug discovery.
In vitro assays are categorized according to the type of targets. Click on any link below for further information.
GPCR Drug Discovery In Vitro Assays
Researchers have found that 475 drugs target 108 different GPCRs. Currently, 321 drugs are undergoing clinical trials, 20% of which are 66 potentially novel GPCR targets that are still unidentified and untreated. Creative Biolabs offers a wide range of GPCR in vitro assays to evaluate the therapeutic effects of your candidate against the membrane protein targets.
Ion Channel Drug Discovery In Vitro Assays
Numerous diseases impair ion channels' ability to operate normally, which has terrible effects on the body. Channelopathies are ion channel and their modulator disorders caused by genetic and autoimmune factors. Ion channel in vitro assays are available from Creative Biolabs to assess the therapeutic effects of your candidate against the membrane protein targets.
Nuclear Receptor Drug Discovery In Vitro Assays
Multifunctional proteins called nuclear receptors translate signals from their specific ligands. Natural hormones and other small lipophilic compounds bind to nuclear receptors in the cytoplasm (type I NR) or nucleus (type II NR) of the cell after diffusing past the cell membrane. Nuclear receptor in vitro tests are available from Creative Biolabs to assess the therapeutic effects of your candidate against the targets.
Transporter Drug Discovery In Vitro Assays
A membrane protein called a transporter facilitates the passage of ions, small chemicals, and macromolecules like proteins across a biological membrane. The transporters may assist in the transportation of molecules by facilitated diffusion or active transport. To assess the therapeutic effects of your candidate against the targets, Creative Biolabs offers transporter In Vitro tests.
Kinases/Enzyme Drug Discovery In Vitro Assays
A phosphate moiety is transferred by kinases from a high-energy molecule (like ATP) to their substrate molecule. The phosphoryl group and substrate of kinases are positioned correctly within their active areas, which speeds up the process. Kinases/enzyme in vitro assays are available from Creative Biolabs to assess the therapeutic effects of your candidate against the targets.
Immune Checkpoint Drug Discovery In Vitro Assays
Immune checkpoints control the immune system by preventing self-attack by cells. Immunotherapies based on cancer antibodies target inhibitory checkpoints. Immunological checkpoint inhibitors are created to disable immune checkpoints, eradicate cancer cells, and preserve immune homeostasis. In vitro immune checkpoint assays are available from Creative Biolabs to assess the therapeutic effects of your candidate against the targets.
