Membrane Lipid Supplement Products
Creative Biolabs can offer membrane lipid supplement products to increase the yields of the majority of bioproducts for cell lines.
More than 4000 distinct lipid species, along with associated enzymes and pathways, are intricately adjusted and controlled in cells to maximize their biochemical and biophysical properties. The majority of cellular functions are influenced by membranes, which make up more than 50% of the total weight and volume of a cell and are crucial to cell physiology. The lipid composition and biophysical characteristics of the membrane network of cultivated cells are currently greatly altered as a result of the existing cultivation techniques, which do not ensure that most cell culture processes will be fully effective. To increase the yields of the majority of bioproducts for cell lines, such as mammalian cells (CHO, HEK, etc.), insect cells, or microorganism cells (E.coli, Yeast, etc.), Creative Biolabs offers membrane lipid supplements.
Fig.1 Cell membrane. (Wikipedia)
Features of Membrane Lipid Supplements
- Biomanufacturing
Our membrane lipid supplements are a multiplier complement to all other technologies, increasing the production of bioproducts. They can complement any cell lines used in bioprocesses, including mammalian cells, insect cells, or microbiological cells, to boost the yields of the majority of bioproducts.
- Advanced therapies
Our membrane lipid supplements can encourage the creation of more effective advanced therapeutic pharmaceuticals and more effective expansion processes.
- In-vitro testing
Our membrane lipid supplements enhance the accuracy of in-vitro models by focusing on the lipidomic signature of cell membranes and related characteristics. They can be applied to evolving in-vitro models that can replicate in-vivo physiology, reducing the need for animal testing and experimental bias.
Applications of Membrane Lipid Supplements
- Recombinant proteins, mAbs and vaccines
Lipids have a significant impact on most aspects of cellular function, including exocytosis, trafficking, and duplication rates. Membrane lipid additives are tailored to properly fit a particular manufacturing method and can boost protein and plasmid yield in a variety of cell factories.
- Viruses and related products
The viral replication cycle is significantly influenced by lipids, which have an impact on viral entry, replication, membrane targeting, assembly, budding, and maturation. Moreover, the envelope's characteristics are altered by the altering of its lipid composition, which has a direct impact on the infectiousness of viruses.
- Gene therapies and Immunotherapies
Membrane lipids have a significant impact on almost all cellular functions and are essential for the operation of immune systems. The fine-tuning of membrane lipids gives you the option to tailor cell behavior according to your demands.
- Extracellular Vesicles and Exosomes
The number and characteristics of EVs and exosomes, which are formed from membrane structures, are greatly regulated by the lipid availability and membrane phenotype. Moreover, when released locally, vehiculated bioactive lipids perform significant roles.
- Drug Discovery and Development
Experimental biases caused by the changed membrane lipid composition of cultivated cells have a significant impact on subsequent animal experiments and clinical trials. The extraordinarily high failure rates of drug development can be partially attributed to this characteristic.
