Membrane-based Drug Delivery Systems
The golden goal of pharmaceutical research has long been the precise delivery of medications to a target lesion, producing maximum therapeutic efficacy with minimal adverse effects. Small-molecule medicines, nucleic acids, and proteins in particular, have poor solubility, low stability, and poor membrane permeability, which result in quick elimination, suboptimal biodistribution, and unintended harm to normal tissues. These challenges are inherent concerns with free medications. Because they have successfully improved druggability by overcoming the physicochemical restrictions of free drugs and by overcoming the physiological barriers to drug delivery, research and development of nanoparticulate drug delivery systems have experienced rapid growth and gained great interest, supported by significant advances in nanotechnology.
The development of membrane-based drug delivery devices has been extensively studied and developed by Creative Biolabs. Our drug delivery system development offerings include Membrane Vesicles (Extracellular Vesicles), Lipid Nanoparticles, Lipid Nanoparticles, Cell Membrane-coated Nanoparticles and Membrane Protein-based Specific Cell Type Targeting Tools.
Click on any link below for further information about our membrane-based drug delivery systems:
Membrane Vesicles (Extracellular Vesicles)
Lipid-based nanocarriers provide a flexible framework for drug encapsulation, which has helped various formulations reach the clinical stage. Extracellular-vesicle (EV)-based carrier systems produced from cells have garnered a lot of interest in addition to synthetic nanocarriers. Creative Biolabs provides EV engineering and functionalization products for our global customers.
Fig.1 Extracellular Vesicles. (Herrmann, 2021)
Lipid Nanoparticles
Lipid nanoparticles have become popular in the pharmaceutical sector as potential delivery systems for a range of medicinal medicines. Lipid nanoparticles are now being used in a variety of industries, including agriculture, nutrition, and other cutting-edge ones like nanoreactors. Creative Biolabs develops and provides customized lipid nanoparticle drug delivery systems.
Glycerosomes
Glycerosomes are microscopic vesicular structures made of phospholipids and water that can transport the active ingredients in a topical application. Glycerosomal vesicles primarily serve to safeguard and facilitate the penetration of active ingredients into the deeper layers of the skin. Creative Biolabs produces and provides glycerosomes for drug delivery applications.
Cell Membrane-coated Nanoparticles
The unique characteristics of cell membrane coated nanoparticles, such as immune evasion, prolonged blood circulation time, precise molecular recognition, and cell targeting, have recently been acknowledged as promising nanomedical tools. Creative Biolabs provides drug delivery tools utilizing the innovative approach of CMNPs.
Membrane Protein-based Specific Cell Type Targeting Tools
Additionally, Creative Biolabs provides specialized goods for the creation and synthesis of targeted agents based on membrane proteins. For a variety of applications in drug delivery, our experts design and engineer highly precise and stable targeting tools using cutting-edge molecular biology techniques.
Reference
- Herrmann, I.K.; et al. Extracellular vesicles as a next-generation drug delivery platform. Nature nanotechnology. 2021, 16(7): 748-759.
