FFAR2
Short chain fatty acids (SCFAs), a key byproduct of dietary fiber digestion, activate this G protein-coupled receptor, which controls intestinal immunity as well as the body's overall energy homeostasis. The gut microbiota of omnivorous mammals, which breaks down dietary fibers, is principally responsible for producing the short chain fatty acids acetate, propionate, and butyrate. SCFAs function as both energy producers and signaling molecules. The G(i/o)-alpha family of G proteins, which are pertussis toxin-sensitive, as well as the Gq family are likely connected to that G protein-coupled receptor. When it is activated, inositol 1,4,5-trisphosphate is produced, intracellular calcium is mobilized, the MAPK3/ERK1 and MAPK1/ERK2 kinases are phosphorylated, and intracellular cAMP buildup is inhibited.
| Full Name | Free fatty acid receptor 2 |
| Gene ID | Human: 2867 Mouse: 233079 Rat: 292794 Monkey: 709026 |
| UniProt ID | Human: O15552 Mouse: Q8VCK6 Rat: Q76EI6 Monkey: A0A2K5UIL9 |
| Alternative Names | FFA2R; GPR43; G-protein coupled receptor 43; fatty acid receptor 2; free fatty acid activated receptor 2; FFAR2; Free fatty acid receptor 2 |
Product List
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Magic™ Cynomolgus monkey FLAG tagged FFAR2 CHO-K1 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX339]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Cynomolgus monkey Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Magic™ Dog FLAG tagged FFAR2 CHO-K1 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX338]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Dog Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Magic™ Human FFAR2 CHO-K1/Gα15 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX53]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free fatty acid receptor Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1/Gα15 Assay Types: Calcium flux assay
Magic™ Human FFAR2 U2OS Cell Line with pLuc Reporter, LinkLight Assay
[CAT#: S01YF-0323-KX55]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Family Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
Magic™ Human FLAG tagged FFAR2 CHO-K1 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX334]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Magic™ Human FLAG tagged FFAR2 CHO-K1 Cell Line, cAMP assay
[CAT#: S01YF-1022-KX341]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: cAMP assay
Magic™ Human FLAG tagged FFAR2 CHO-K1 Gα16 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX335]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Gα16 Assay Types: Calcium flux assay
Magic™ Human FLAG tagged FFAR2 CHO-K1 Gαqi5 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX342]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Gαqi5 Assay Types: Calcium flux assay
Magic™ Human FLAG tagged FFAR2 HEK293T Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX333]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
Magic™ Mouse FLAG tagged FFAR2 HEK293T Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX336]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Mouse Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
Magic™ mPro Human FFAR2 Cell Line
[CAT#: S01YF-1122-KX30]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Receptors Target Protein Species: Human
Magic™ Rat FLAG tagged FFAR2 HEK293T Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX337]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Rat Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
Magic™ Rhesus monkey FLAG tagged FFAR2 CHO-K1 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX340]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Target Protein Species: Rhesus monkey Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
mProX™ Human FFAR2 Stable Cell Line
[CAT#: S01YF-0923-PY67]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FFAR2 Target Family: Free Fatty Acid Family Target Protein Species: Human Host Cell Type: HOS;CHO-K1;HEK293
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