Membrane Protein Drug Discovery Services

Creative Biolabs offers high-quality membrane protein drug discovery service and related membrane protein products to advance your membrane protein drug discovery researches. Our versatile membrane protein drug discovery platform employs diverse techniques, including high throughput screening, virtual drug screening, etc.

Integral membrane proteins (MPs) are important targets in various sectors of drug discovery, but generating them in functional forms has historically been a major hurdle for drug development. The state of the art in drug discovery tactics employs recombinant multipass MPs and outlines ways for successfully expressing, stabilizing, and formulating them for the production of small molecules and monoclonal antibody therapies. Advances in structure-based drug design and high-throughput screening are allowing researchers to get access to previously inaccessible targets including GPCR, ion channels, and transporters, paving the way for the development of highly selective medicines that target specific conformations.

Fig.1. Membrane protein.

GPCR Drug Discovery Services

Creative Biolabs is proud to offer our clients a series of GPCR drug discovery services with the best quality and most competitive price.

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Membrane Protein Virtual Drug Screening Services

Creative Biolabs provides high quality virtual drug screening service to identify most promising candidates.

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Membrane Protein DNA-encoded Library Screening Services

Creative Biolabs has long-term devoted to developing and optimizing the efficiency of membrane protein drug discovery.

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Ion Channel Screening Services

Creative Biolabs can test against a variety of ion channels and transporters with HTS ion channel screening techniques.

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Many existing drugs acting on MPs have significant drawbacks, such as lack of specificity due to similar ligand-binding pockets in related MPs, or unwanted effects due to their involvement in a variety of signaling pathways that can have a significant impact on overall cell equilibrium conditions, such as ion channels and transporters. These can manifest as negative safety and side-effect profiles, highlighting the need for treatments that target specific MP conformations or signaling pathways, allowing for increased drug affinity, specificity, and potency, among other benefits. Targeting MPs with monoclonal antibodies (mAbs) is one strategy to achieve target selectivity, especially when the mAb identifies a conformational epitope, such as when the mAb is created against a full-length MP.

Creative Biolabs has more than a decade of experience in drug discovery for innovative, first-in-class targets as well as quick follow-on targets. The membrane protein drug discovery services platform from Creative Biolabs offers deep experience and broad capabilities in a variety of therapeutic areas, including Metabolic Disorders, Inflammatory and Autoimmune Diseases, Pain, CNS Disorders, and Gastrointestinal Disorders. Please contact us for more details about our membrane protein drug discovery services.

Reference

1. Gulezian, E., et al. Membrane protein production and formulation for drug discovery. Trends in Pharmacological Sciences. 2021; 42(8): 657-674.