Chemokine GPCR Assays

Overview of Chemokine Receptors

Chemokines, a family of secreted cytokines, are involved in the regulation of various physiological and pathological processes. Chemokines are classified into four subfamilies according to the assembly of cysteine residues: CC, XC, CXC, and CX3C. Chemokines are composed of chemokine ligands and receptors. Chemokine receptors are expressed on all leukocytes and can be divided into two groups: G protein-coupled chemokine receptors (GPCRs) and atypical chemokine receptors (ACKRs). It is worth noting that many chemokine ligands can bind to multiple receptors and some receptors have many ligands.

Fig.1. Functions of chemokines and their receptors. (Hughes, 2028)

Chemokine Receptors and Diseases

Chemokines play multiple roles in a variety of life activities, such as chemotaxis, leukocyte migration, cell proliferation, and survival. Due to their vital roles, chemokines have always been relevant to many human disorders, such as inflammation, cancer, allergy, viral infections, atherosclerosis, and autoimmune diseases. Activation of chemokine-mediated signaling pathways requires selective binding of chemokines to receptors. Chemokines from four subfamilies activate diverse receptors. Chemokines and chemokine receptors are potential therapeutic targets for antagonists aimed at blocking chemokine receptor-ligand interactions.

The table lists the types of general chemokine receptors and their main mechanisms.

Assay List of Chemokine Receptors

Creative Biolabs can provide a range of assays of chemokine receptors. You can choose the assay in the list or contact us for more information:

Published Data

References

1. Hughes, C. E.; Nibbs, R. J. A guide to chemokines and their receptors. The FEBS journal. 2018; 285(16): 2944-2971.
2. Khalil, B.A.; et al. Chemokines and chemokine receptors during COVID-19 infection. Computational and structural biotechnology journal. 2021; 19: 976-988.