CXCR2
This gene encodes a protein that belongs to the family of G-protein-coupled receptors. This protein serves as the interleukin 8 receptor (IL8). It has a strong affinity for IL8 and transmits the signal using a second messenger pathway that is triggered by G proteins. This receptor has been demonstrated to be a key element needed for serum-dependent melanoma cell growth and binds to the protein chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), which has been found to have melanoma growth promoting action. The migration of neutrophils to inflammatory areas is mediated by this receptor. It is discovered that this receptor mediates the angiogenic effects of IL8 in intestinal microvascular endothelial cells. Studies using animals with this receptor's knockout revealed that this receptor regulates the location of oligodendrocyte progenitors by halting their migration.
| Full Name | C-X-C motif chemokine receptor 2 |
| Gene ID | Human: 3579 Mouse: 12765 Rat: 29385 Monkey: 700407 |
| UniProt ID | Human: P25025 Mouse: P35343 Rat: P35407 Monkey: Q28519 |
| Alternative Names | CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; IL-8 receptor type 2 IL-8R B; chemokine (CXC) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B; CXCR2; C-X-C motif chemokine receptor 2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Gαqi5 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: U937;Molm13;CHO-K1;HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: CHO-S Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR2 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
