ACKR3
A member of the family of G-protein coupled receptors is encoded by this gene. Although this protein was once supposed to be a vasoactive intestinal peptide (VIP) receptor, its endogenous ligand has not been discovered, hence it is currently thought to be an orphan receptor. Additionally, the protein functions as a coreceptor for HIVs (HIV). Atypical chemokine receptor that regulates chemokine concentrations and location through high-affinity chemokine binding that is decoupled from traditional ligand-driven signal transduction pathways and leads to chemokine sequestration, degradation, or transcytosis instead.
| Full Name | Atypical chemokine receptor 3 |
| Gene ID | Human: 57007 Mouse: 12778 Rat: 84348 Monkey: 694428 |
| UniProt ID | Human: P25106 Mouse: P56485 Rat: O89039 Monkey: A0A2K6T558 |
| Alternative Names | ACKR3; RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; C-X-C chemokine receptor type 7; G protein-coupled receptor; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1; Atypical chemokine receptor 3 |
Product List
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Magic™ Human ACKR3 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay
[CAT#: S01YF-1222-KX34]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACKR3 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
Magic™ Human ACKR3 U2OS Cell Line with pLuc Reporter, LinkLight Assay
[CAT#: S01YF-0323-KX74]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACKR3 Target Family: Chemokine Family Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
Magic™ Human FLAG tagged ACKR3 & ARRB2 HEK293T β-Arrestin2 Cell Line, β-Arrestin Assay
[CAT#: S01YF-1022-KX285]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACKR3; ARRB2 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T β-Arrestin2 Assay Types: β-Arrestin Assay
Magic™ Human FLAG tagged ACKR3 HEK293T Cell Line
[CAT#: S01YF-1022-KX284]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACKR3 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T
mProX™ Human ACKR3 Stable Cell Line
[CAT#: S01YF-0923-PY50]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ACKR3 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: Huh-7;SNU387;CHO-K1;HEK293
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