CXCR4
A CXC chemokine receptor specific for stromal cell-derived factor-1 is encoded by this gene. The protein is found on the cell surface and has seven transmembrane areas. In addition to being highly expressed in breast cancer cells, it collaborates with the CD4 protein to facilitate HIV entrance into cells. WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome has been linked to mutations in this gene. By boosting MAPK1/MAPK3 activation and intracellular calcium ion levels, CXCR3 transmits a signal. a part of the AKT signaling chain. plays a part in controlling cell migration, for instance during the healing of wounds. acts as a ubiquitin receptor, increasing intracellular calcium ions and decreasing cellular cAMP levels.
| Full Name | C-X-C motif chemokine receptor 4 |
| Gene ID | Human: 7852 Mouse: 12767 Rat: 60628 Monkey: 707329 |
| UniProt ID | Human: P61073 Mouse: P70658 Rat: O08565 Monkey: P79394 |
| Alternative Names | FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3 SDF-1 receptor; chemokine (C-X-C motif) receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3 neuropeptide Y3 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; CXCR4; C-X-C motif chemokine receptor 4 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR4 Target Family: Chemokine receptor Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1/Gα15 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR4 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR4 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: MDA-MB-231;CHO-K1;HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR4 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CXCR4 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Gαqi5 Assay Types: Calcium flux assay
