CCR2
This gene encodes a protein that functions as a receptor for monocyte chemoattractant protein-1, a chemokine that specifically controls the movement of monocytes. The inflammatory response against malignancies and monocyte infiltration in inflammatory disorders like rheumatoid arthritis are both mediated by monocyte chemoattractant protein-1. The encoded protein controls the inhibition of adenylyl cyclase and agonist-dependent calcium mobilization. This protein can function as a coreceptor for HIV-1 infection alongside CD4. CCR5 Pathway in Macrophages and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions are two of its associated pathways. This gene's Gene Ontology (GO) annotations include chemokine receptor activity and G protein-coupled receptor activity.
| Full Name | C-C motif chemokine receptor 2 |
| Gene ID | Human: 729230 Mouse: 12772 Rat: 60463 Monkey: 574098 |
| UniProt ID | Human: P41597 Mouse: P51683 Rat: O55193 Monkey: O18793 |
| Alternative Names | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; C-C chemokine receptor type 2; MCP-1 receptor; chemokine (C-C motif) receptor 2; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; CCR2; C-C motif chemokine receptor 2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2B Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2B Target Family: Chemokine Receptors Target Protein Species: Human
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 Host Cell Type: THP-1
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 (Middle) Target Family: Chemokine Receptors Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 (High) Target Family: Chemokine Receptors Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR2 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: PC3;C4-2B;CHO-K1;HEK293
