CCR4
This gene encodes a protein that is a member of the G-protein-coupled receptor family. It is a CC chemokine receptor for MIP-1, RANTES, TARC, and MCP-1. Chemokines are a family of tiny, structurally similar polypeptide molecules that control how different kinds of leukocytes move around inside their cells. The chemokines also have important impacts on cells of the central nervous system and endothelial cells engaged in angiogenesis or angiostasis, as well as on immune system development, homeostasis, and function. G(i) proteins, which activate a phosphatidylinositol-calcium second messenger system, mediate the function of this receptor. Can operate as a coreceptor for some initial HIV-2 isolates and as a chemoattractant homing receptor on circulating memory cells.
| Full Name | C-C motif chemokine receptor 4 |
| Gene ID | Human: 1233 Mouse: 12773 Rat: 171054 Monkey: 705457 |
| UniProt ID | Human: Q9ULM6 Mouse: P51680 Rat: Q9ET55 Monkey: A0A2K6TZM7 |
| Alternative Names | CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; C-C CKR-4; CCR-4; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; CCR4; C-C motif chemokine receptor 4 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Receptors Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Receptors Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Gαqi5 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCR4 Target Family: Chemokine Family Target Protein Species: Human Host Cell Type: MDA-MB-231;CHO-K1;HEK293
