Membrane Protein Lentivirus
Creative Biolabs has developed a comprehensive list of membrane protein tools to support the development of antibody and other therapeutic. We are dedicated to bringing more value to our clients by providing stock products, more technical resources and custom protein production services.
Background of Membrane Protein
About one-third of all proteins in living things are membrane proteins. Membrane proteins can be divided into three groups based on their structural characteristics: integral membrane proteins, which are permanently anchored to or a part of the membrane; peripheral membrane proteins, which are momentarily attached to the lipid bilayer or to other integral proteins; and lipid-anchored proteins. Membrane proteins, such as membrane receptors, ion channels, GPCRs (G protein-coupled receptors), and different transport proteins, play important functions in all organisms. membrane receptors, which are located in cell membranes and can communicate with both the cell's internal environment and its exterior environment. Some enzymes, such oxidoreductase, transferase, and hydrolase, are also membrane proteins. Cell adhesion molecules, which are found on the cell surface and involved in interacting with extracellular matrix (ECM) or other cells, enable cells to recognize and communicate with one another.
Application of Membrane Protein Lentivirus
The lentivirus produced by Creative Biolabs are enveloped viruses that enter cells by fusing with membranes. Our lentivirus is made up of vector particles containing glycoproteins from other enveloped viruses, specifically the vesicular stomatitis virus (VSV-G). Given the stability and extensive host range that VSV-G pseudotyping offers, these virus particles are very helpful for attacking many cell types.
Feature of Membrane Protein Lentivirus
- Infect both actively-dividing and non-dividing cells.
- Infect a variety of cell stages.
- Ideal for transducing stem cells or primary cells that may be resistant to other transduction techniques.
- Up to 10 kb of DNA can be inserted.
- Long-lasting, reliable transgene expression.
