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    mProX™ Human S1PR1 Stable Cell Line

    [CAT#: S01YF-0923-PY102]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX576 Magic™ Rat S1PR1 in Vitro Calcium Flux Assay Rat CHO-K1-Gqi5 Calcium Flux Assay
    S01YF-1122-KX577 Magic™ Rat S1PR1 in Vitro cAMP Assay Rat CHO-K1 cAMP Assay

    Product Information

    Target Protein
    S1PR1
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Human
    Host Cell Type
    Huh7;SK-Hep1;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research;CNS Research
    Related Diseases
    Dermatitis, Atopic, 7;Second-Degree Atrioventricular Block
    Gene ID
    Human: 1901
    UniProt ID
    Human: P21453

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Sphingosine-1-phosphate receptor 1 (S1PR1) is a central figure in scientific explorations, particularly in the context of vascular biology and immunology. It has been found to play a role in hepatocellular carcinoma progression by influencing metabolic reprogramming of ceramide in vascular endothelial cells. Additionally, its involvement in modulating the allogeneic response of T cells, impacting graft-versus-host disease, has been highlighted. The potential of S1PR1 as a therapeutic target is evident, with agonists and antagonists being developed to modulate its activity in various diseases.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human S1PR1 Stable Cell Line (S01YF-0923-PY102). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat John (Verified Customer)

    How does S1PR1 signaling contribute to the survival of retinal ganglion cells in experimental glaucoma? Jan 08 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    S1PR1 signaling plays a vital role in the survival of retinal ganglion cells and neurons in the dorsolateral geniculate nucleus in experimental glaucoma. Siponimod, an S1PR1 modulator, exerts direct neuroprotective effects, indicating a potential therapeutic application for glaucoma patients. Jan 08 2023

    chat Nancy (Verified Customer)

    What is the role of S1PR1 in the regulation of IL-1β expression during NDV infection? Jul 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    NDV infection promotes S1PR1 expression and induces IL-1β expression through p38, JNK/MAPK, and NLRP3/caspase-1 inflammasomes. S1PR1 regulates IL-1β expression mainly through the NLRP3/caspase-1 inflammasome, suggesting a potential target for modulating immune responses during viral infections. Jul 18 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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