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    mProX™ Human EDNRA Stable Cell Line

    [CAT#: S01YF-0923-PY64]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    EDNRA
    Target Family
    Endothelin Family
    Target Protein Species
    Human
    Host Cell Type
    KIM-1;KYN-2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Mandibulofacial Dysostosis With Alopecia;Migraine With Or Without Aura 1
    Gene ID
    Human: 1909
    UniProt ID
    Human: P25101

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Endothelin Receptor Type A (EDNRA) plays a pivotal role in various vascular and non-vascular diseases. Recent studies have highlighted its involvement in pathological vascular remodeling, where compounds like Andrographolide have been shown to regulate the endothelin signaling pathway by inducing EDNRA expression. Furthermore, polymorphisms in the EDNRA gene have been linked to susceptibility to large artery atherosclerotic stroke in certain populations. Additionally, the EDN1/EDNRA/β-arrestin axis has been implicated in the progression of colorectal cancer, emphasizing the significance of EDNRA in cancer research3.

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    FAQ

    chat Kevin (Verified Customer)

    How is EDNRA significant in vascular research? Sep 04 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EDNRA, or endothelin receptor type A, is a receptor for endothelins, which are potent vasoconstrictors. It has been associated with pathological vascular remodeling. For instance, andrographolide has been shown to regulate smooth muscle cell (SMC) phenotypic switching and activate the endothelin signaling pathway by inducing EDNRA expression. This suggests a potential therapeutic role for modulating EDNRA in vascular diseases. Sep 04 2023

    chat James (Verified Customer)

    What is the association between EDNRA and cancer? Aug 22 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EDNRA has been implicated in the progression of colorectal cancer. Elevated EDNRA expression levels have been observed in colorectal cancer tissues, and its antagonism has shown potential in suppressing tumor growth and migration. This highlights the importance of the endothelin signaling pathway in tumorigenesis and offers potential therapeutic avenues. Aug 22 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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