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  • Human EDNRA Membrane Protein LNP Encapsulation mRNA

    [CAT#: S01YF-1124-KX271]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein mRNA

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    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order LNP-mRNA encoding human EDNRA.
    Target Protein
    EDNRA
    Target Protein Species
    Human
    Target Classificationp
    GPCR
    Target Research Area
    Cardiovascular Research; CNS Research; Pain and Addiction Research
    Related Diseases
    Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura
    Target Family
    Endothelin Receptor
    RNA Type
    LNP-mRNA
    Nucleoside Modification Method
    m1Ψ; m5C or specific requirements
    Cap
    Cap 0; Cap 1 or specific requirements
    PolyA Tail (nt)
    30 nt; 80 nt; 120 nt or specific requirements
    5' UTR
    Human globin alpha; 5' UTR seq can be modified according to the specific requirements
    Promoter
    T7
    Tag
    Based on specific requirements
    Fluorescent Markers
    Based on specific requirements
    Formation
    LNP Encapsulation mRNA
    LNP Formulation
    Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
    Buffer
    Tris buffer or PBS

    Quality Control

    OD260/280 (~1.90-2.50)
    PASS
    Agarose Gel Mobility
    PASS
    Sequence and Enzyme Digestion
    PASS
    Encapsulation Efficiency
    PASS
    mRNA Transfection Efficiency
    PASS

    Product Properties

    Application
    Drug discovery research and pre-clinical studies
    Shipping
    Blue Ice
    Storage
    Aliquot and store at 2-8°C for long term.

    Target

    Full Name
    Endothelin receptor type A
    Introduction
    This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
    Alternative Names
    ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor; EDNRA; Endothelin receptor type A
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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