mProX™ Human VIPR1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Morphology of rat vaginal SMCs under an inverted microscope.
The inhibitory effect of miR-122-5p overexpression on the relaxation of rat vaginal smooth muscle cells (SMCs) was reversed by overexpression of the vasoactive intestinal peptide receptor 1 (VIPR1).
Ref: Cong, Shengnan, et al. "Overexpressing miR-122-5p Inhibits the Relaxation of Vaginal Smooth Muscle in Female Sexual Arousal Disorder by Targeting Vasoactive Intestinal Peptide Receptor 1." Sexual Medicine 9.4 (2021): 100390-100390.
Pubmed: 34246178
DOI: 10.1016/j.esxm.2021.100390
Research Highlights
This study discovered that VIPR1 greatly reduced the proliferation, migration, and invasion of H1299 cells after it was overexpressed.
Zhao, Lufeng, Zipu Yu, and Baiqin Zhao. "Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cells." Medical oncology 36 (2019): 1-7.
Pubmed:
31560089
DOI:
10.1007/s12032-019-1312-y
In HCC, deacetylation of H3K27 in the VIPR1 promoter reduced VIPR1 transcription. As a result, HCC patients with reduced VIPR1 expression have a worse prognosis, and this expression is at least partially driven by epigenetic alteration.
Lu, Sicong, et al. "Promoter methylation and H3K27 deacetylation regulate the transcription of VIPR1 in hepatocellular carcinoma." Biochemical and biophysical research communications 509.1 (2019): 301-305.
Pubmed:
30583864
DOI:
10.1016/j.bbrc.2018.12.129
