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    mProX™ Human PDCD1 Stable Cell Line

    [CAT#: S01YF-1023-PY165]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;H9C2
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Systemic Lupus Erythematosus 2; Multiple Sclerosis
    Gene ID
    Human:5133
    UniProt ID
    Human:Q15116

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PDCD1, also known as PD-1, is a gene that plays a role in the immune response and has applications in various types of cancer. In gastric cancer, a study found that high expression of PDCD1 was associated with a less favorable outcome, and the gene was positively linked to the expression of immune checkpoints. In hepatocellular carcinoma, overexpression of PDCD1 was associated with cancer progression and immune cell infiltration. In endometrial cancer, PDCD1 was identified as part of an inflammatory response-related signature that had prognostic value and could enhance targeted therapy. Additionally, in CAR T cell therapy, deleting the CTLA4 gene, which is related to PDCD1, was found to enhance the function of CAR T cells. Overall, PDCD1 has implications for understanding the tumor immune microenvironment, predicting patient outcomes, and improving immunotherapeutic strategies in various cancers.

    Protocols

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    FAQ

    chat Morgan Garcia (Verified Customer)

    How does PDCD1 polymorphism influence the efficacy of immunotherapy? May 31 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PDCD1 polymorphisms, like PD-1.6, can be associated with the occurrence of severe immune-related adverse events in patients treated with immunotherapy, indicating its potential role in predicting treatment response. May 31 2022

    chat Casey Brown (Verified Customer)

    Can altering PDCD1 expression patterns overcome T cell exhaustion? Oct 14 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Using CRISPR/Cas9 exon skipping strategy to modify PD-1 expression patterns in T cells could help overcome T cell exhaustion, a potential approach for adoptive cell immunotherapies. Oct 14 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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