mProX™ Human P2RY12 Stable Cell Line
[CAT#: S01YF-0923-KX17]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
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InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
In order to distinguish healthy mouse CNS microglial cells from other cell types such as tissue-resident macrophages or blood-derived monocytes, the purinergic receptor P2Y12 (P2RY12) was proposed as a unique marker for these cells. A unique marker for microglial cells in human brains, P2RY12, has been proposed. P2RY12 is a member of the P2 purinergic receptor family, which also includes seven other transmembrane G protein coupled receptors (GPCRs) involved in ATP- and ADP-mediated in vitro cell motility. In addition to microglial cells, active platelets also express P2RY12. In P2RY12 knockdown animals, microglial chemotaxis and the expansion of microglial foot processes in response to CNS damage were severely impaired. The customized P2RY12 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Ava
The P2RY12 Stable Cell Line is great for cardiovascular research.
Dec 24 2022
Verified Customer
Ethan
Flow cytometry is used to verify the surface expression of the P2RY12 protein, and qPCR is used to verify the engineering results at the mRNA level.
Jul 19 2022
Verified Customer
FAQ
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