mProX™ Human HLA-A Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

HLA-A, or human leukocyte antigen A, has various applications in different fields. In a study on metastatic uveal melanoma, HLA-A*02:01 was found to be a positive marker for patients who responded well to tebentafusp treatment, leading to improved overall survival rates. Another study focused on Alzheimer's disease and used single-cell transcriptome analysis to identify GZMK (+) CD8 (+) T cells in peripheral blood as potential biomarkers. These cells were found to be increased in AD patients and may be associated with abnormal signal transduction of major histocompatibility complex class ,Ö† (MHC-,Ö†). In a study on placental pathology, it was observed that inflammatory placental lesions were specifically present in healthy oocyte donation pregnancies with extreme fetal-maternal incompatibility. These lesions were associated with fetal-maternal HLA incompatibility and may play a role in protecting these pregnancies from complications. Lastly, HLA-A alleles are also important in the field of genetics and genomics. A novel HLA-A*03:01:120 allele was identified using next-generation sequencing technology. Overall, HLA-A has implications in cancer treatment, neurodegenerative diseases, pregnancy complications, and genetic studies.