mProX™ Human HLA-A Stable Cell Line

Product Information

Target Family

HLA

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1

Target Classification

HLA Cell Lines

Target Research Area

Ocular Research

Related Diseases

Severe Cutaneous Adverse Reaction; Birdshot Chorioretinopathy

Gene ID

Human:3105

UniProt ID

Human:P04439

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

HLA-A, or human leukocyte antigen A, has various applications in different fields. In a study on metastatic uveal melanoma, HLA-A*02:01 was found to be a positive marker for patients who responded well to tebentafusp treatment, leading to improved overall survival rates. Another study focused on Alzheimer's disease and used single-cell transcriptome analysis to identify GZMK (+) CD8 (+) T cells in peripheral blood as potential biomarkers. These cells were found to be increased in AD patients and may be associated with abnormal signal transduction of major histocompatibility complex class ,Ö† (MHC-,Ö†). In a study on placental pathology, it was observed that inflammatory placental lesions were specifically present in healthy oocyte donation pregnancies with extreme fetal-maternal incompatibility. These lesions were associated with fetal-maternal HLA incompatibility and may play a role in protecting these pregnancies from complications. Lastly, HLA-A alleles are also important in the field of genetics and genomics. A novel HLA-A*03:01:120 allele was identified using next-generation sequencing technology. Overall, HLA-A has implications in cancer treatment, neurodegenerative diseases, pregnancy complications, and genetic studies.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Johnson (Verified Customer)

What is the significance of HLA-A in viral infections? Mar 17 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

HLA-A plays a crucial role in the immune response to viral infections, such as Epstein-Barr virus, by presenting viral antigens to T cells. Mar 17 2022

chat Alex Brown (Verified Customer)

How does HLA-A contribute to disease susceptibility? Mar 29 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Variations in HLA-A are associated with susceptibility to diseases like HIV and carbamazepine-induced hypersensitivity reactions, indicating its role in disease progression and drug response. Mar 29 2022

Published Data

Fig.1 In vitro infection with HIV was performed on CD4 cells purified from normal donor 2, and subsequent representative flow cytometry staining of each HLA locus was carried out on the infected cells.

Following the gating of the CD3+ CD8- population, discrimination between infected (CD4-) and uninfected (CD4+) cells in a culture (x-axis) was accomplished through the utilization of CD4 downregulation. Subsequent measurement of staining for each classical HLA class-I locus (y-axis) was carried out. The relative staining of HLA-A (green), HLA-B (red), HLA-C (blue), and isotype control (black) was displayed in distinct histograms for uninfected (left) and infected (right) cells from the culture.

Ref: Apps, Richard, et al. "Relative expression levels of the HLA class-I proteins in normal and HIV-infected cells." The Journal of Immunology 194.8 (2015): 3594-3600.

Pubmed: 25754738

DOI: 10.4049/jimmunol.1403234

Research Highlights

C Hassel, Jessica. et al. "Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma." The New England journal of medicine, 2023.
Tebentafusp, a T-cell receptor-bispecific molecule that targets glycoprotein 100 and CD3, has been approved for use in adult patients positive for HLA-A*02:01 and with unresectable or metastatic uveal melanoma. A long-term survival benefit has been found in the primary analysis of the current phase 3 trial involving this drug.
C Hassel, Jessica. et al. "Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma." The New England journal of medicine, 2023.
Pubmed: 37870955 DOI: 10.1056/NEJMoa2304753

Duan, Tingting. et al. "Identification of Peripheral Blood GZMK+ CD8+ T Cells As Biomarkers of Alzheimer's Disease Based on Single-Cell Transcriptome." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2023.
This study investigates the use of single-cell RNA sequencing (scRNA-seq) to examine immune features in the peripheral blood of individuals with Alzheimer's disease (AD) as potential biomarkers. The findings suggest that scRNA-seq may be a valuable tool for detecting changes in the immune system associated with AD. This research has important implications for understanding the disease and developing early diagnostic strategies.
Duan, Tingting. et al. "Identification of Peripheral Blood GZMK+ CD8+ T Cells As Biomarkers of Alzheimer's Disease Based on Single-Cell Transcriptome." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2023.
Pubmed: 37866940 DOI: 10.12182/20230960107