HLA Cell Lines
Membrane protein stable cell lines are widely used in many areas of biomedical research. Creative Biolabs can offer membrane protein stable cell lines to stablish in vitro models for High Throughput Screening.
Creative Biolabs offers high-quality, innovative tools to help research groups accelerate membrane protein drug discovery. They can be found by targets. If there is no product that meets your needs, please contact us.
Background of Human Leukocyte Antigen
Human leukocyte antigen (HLA) is the major histocompatibility complex encoded by the HLA gene complex. The gene segment it is located in is also the gene with the highest gene density and the most polymorphisms among human chromosomal regain that we know of. HLAs can be classified into three categories according to their function and structure, and are further subdivided into more than a dozen subgroups. For each person, the HLA protein has a unique structure, and the immune system distinguishes self-cells from non-self-cells based on this structural difference, which leads to an attack against the invaders, so the difference in HLA among people is often the leading cause of organ transplant rejection.
Fig.1 Structure Prediction of HLA class I histocompatibility antigen, alpha chain F.1
Functions and Mechanisms of Human Leukocyte Antigen
When a cell is infected with a virus, class I HLA presents viral fragments from the interior of the cell to killer T cells and binds to KIR molecules on their surface, allowing the cell to be destroyed by the immune system. In contrast, class II HLAs present extracellular antigens to CD4-positive T lymphocytes, which in turn promote B cell expansion, thereby activating the immune response.
Applications and Pathology of HLA Cell Lines
HLA is closely related to the body's immune response, regulation, and monitoring, and is of great significance in the study of autoimmune diseases, tumor immunity, organ transplantation, and reproductive immunity. Overexpression of HLA genes or HLA protein disorder and misfolding can lead to various autoimmune diseases. HLA is the bridge connecting immunology and clinical disease treatment. With the development of research methods and technologies, more discoveries and broader prospects will be made.
