mProX™ Human CXCR2 Stable Cell Line

Product Information

Target Protein

CXCR2

Target Family

Chemokine Family

Target Protein Species

Human

Host Cell Type

U937;Molm13;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Immunology Research

Related Diseases

Whim Syndrome 2;Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency

Gene ID

Human: 3579

UniProt ID

Human: P25025

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CXCR2, a chemokine receptor, has emerged as a pivotal player in the realm of scientific research, particularly in the context of cancer biology and immunology. One of the significant findings is the role of CXCR2 in tumor processes, influencing proliferation, migration, and invasion of tumor cells. Additionally, CXCR2 activation impacts angiogenesis, lymphangiogenesis, and cellular senescence. In the context of lung cancer, targeting CXCR2 has shown to inhibit tumor progression and enhance the therapeutic effect of cisplatin. Furthermore, CXCR2 plays a role in liver recovery post acetaminophen overdose in mice by regulating pro-regenerative gene expression in hepatocytes. The CXCL2/IL8/CXCR2 pathway has also been identified as crucial for brain tumor malignancy and endothelial cell function. Given the breadth of its involvement in various physiological and pathological processes, CXCR2 presents itself as a promising therapeutic target in cancer and other diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Sharon (Verified Customer)

Is CXCR2 only associated with cardiac conditions? Feb 15 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

No, while CXCR2 overexpression has been linked to cardiac muscle loss in cardiac cachexia, it also plays roles in various other conditions such as renal cell carcinoma, Staphylococcus aureus skin infection, and colon cancer. Feb 15 2022

chat Melissa (Verified Customer)

Can CXCR2 be considered a target for cancer treatments? Jan 27 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, several studies have identified CXCR2 as a potential target in various cancers, including renal cell carcinoma and oesophageal squamous cell carcinoma. Jan 27 2023

mProX™ Human CXCR2 Stable Cell Line

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