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    mProX™ Human CXCR1 Stable Cell Line

    [CAT#: S01YF-0923-PY44]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX352 Magic™ Mouse CXCR1 in Vitro Calcium Flux Assay Mouse CHO-K1 Calcium Flux Assay

    Product Information

    Target Protein
    CXCR1
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    Saos2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Human Immunodeficiency Virus Type 1;Acute Pyelonephritis
    Gene ID
    Human: 3577
    UniProt ID
    Human: P25024

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CXCR1, another chemokine receptor, has been extensively studied for its role in various pathological conditions. Its significance in lung cancer development and progression has been emphasized, particularly in the context of tumor microcirculation. In the realm of pancreatic cancer, the combined targeting of T cell checkpoints and CXCR1 has shown promising results in remodeling the tumor microenvironment. Additionally, CXCR1, along with CXCR2, has been identified as a potential therapeutic target for cardiovascular diseases, given its involvement in atherosclerotic plaque formation and blood pressure regulation. The receptor's role in inflammation and nociception has also been explored, suggesting its potential as a therapeutic target for neuropathic conditions. The diverse applications of CXCR1 in scientific research, from oncology to cardiovascular diseases, highlight its potential as a therapeutic target and prognostic biomarker.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CXCR1 Stable Cell Line (S01YF-0923-PY44). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Brian (Verified Customer)

    Is CXCR1 only associated with pancreatic ductal adenocarcinoma (PDAC)? Dec 26 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    No, while CXCR1 has been studied as a marker and therapeutic target for PDAC, it has also been investigated in relation to other diseases such as type 1 diabetes and various forms of cancer, including breast cancer. Dec 26 2021

    chat Melissa (Verified Customer)

    Can targeting CXCR1 alone be effective in treating cancer? Jan 08 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Research suggests that targeting CXCR1 can be beneficial, especially in combination with other treatments. For instance, a study showed that the CXCR1/2 inhibitor reparixin combined with CDK4/6 inhibitors could attenuate endocrine-resistant breast cancer growth and metastasis. Jan 08 2021

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    • mProX™ Human CXCR1 Stable Cell Line (CAT#: S01YF-0923-PY44)
    • Magic™ Human CXCR1 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX29)
    • Magic™ Human FLAG tagged CXCR1 HEK293T Gαqi5 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX272)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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