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    mProX™ Human CX3CR1 Stable Cell Line

    [CAT#: S01YF-0923-PY43]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX348 Magic™ Rat CX3CR1 in Vitro Calcium Flux Assay Rat CHO-K1-Gα16 Calcium Flux Assay

    Product Information

    Target Protein
    CX3CR1
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    GES-1;MKN-28;SGC-7901;MKN-45;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research;Immunology Research
    Related Diseases
    Macular Degeneration, Age-Related, 12;Human Immunodeficiency Virus Type 1
    Gene ID
    Human: 1524
    UniProt ID
    Human: P49238

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CX3CR1, a chemokine receptor, has been the focus of numerous scientific investigations due to its significant implications in various medical conditions. One of the intriguing findings is its association with graft-versus-host disease (GVHD) as a new risk factor, shedding light on its immunologic role. Moreover, CX3CR1's involvement in Alzheimer's disease has been highlighted, where its deficiency exacerbates amyloid-driven neuronal pathology, leading to cognitive decline. This receptor also plays a pivotal role in the tumor microenvironment of colorectal cancer, influencing the recruitment and regulation of immune-infiltrating cells. Furthermore, CX3CR1 has been identified as a potential biomarker in response to immune checkpoint inhibitors, especially in the context of non-small cell lung cancer. The diverse roles of CX3CR1, from neurodegenerative diseases to cancer, underscore its importance in scientific research and potential therapeutic applications.

    Protocols

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    FAQ

    chat Brian (Verified Customer)

    What is the role of CX3CR1 in neuroinflammation and its potential therapeutic implications? Jan 23 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CX3CR1 has been identified to play a significant role in neuroinflammation. For instance, total saponins of panax ginseng have been found to exert antidepressant-like effects in rats by inhibiting the CX3CL1/CX3CR1 axis, thereby attenuating neuroinflammation. Additionally, the dynamics of microglial CX3CR1 through altered FKN signaling has been described as a potential therapeutic consideration, which has been tested in animal models and is expected to be in human clinical trials in the future. Jan 23 2022

    chat Jennifer (Verified Customer)

    How does CX3CR1 influence metastasis in cancer? Nov 13 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CX3CR1 has been associated with metastasis in various cancers. For instance, diet-induced obesity was found to promote liver metastasis of pancreatic ductal adenocarcinoma via the CX3CL1/CX3CR1 axis. Moreover, subsets of cancer cells expressing CX3CR1 have been identified to possess metastasis-initiating properties and resistance to chemotherapy. Nov 13 2020

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    • Magic™ Human CX3CR1 CHO-K1 Cell Line, Binding and Functional Assay (CAT#: S01YF-1222-KX344)
    • Magic™ Human CX3CR1 CHO-K1 Cell Line with Aequorin Reporter, Calcium flux assay (CAT#: S01YF-1222-KX343)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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