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    mProX™ Human CLDN18 Stable Cell Line

    [CAT#: S01YF-1023-PY261]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;BGC-823
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Gastroesophageal Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma
    Gene ID
    Human:51208
    UniProt ID
    Human:P56856

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CLDN18 is a target for antibody-drug conjugates (ADCs) in central nervous system (CNS) tumors. The expression of ADC targets, including CLDN18, in CNS tumors is poorly characterized. However, subtype-specific expression of ADC target proteins was observed in various CNS tumors, suggesting the potential for clinical trials of ADCs in these tumors. Additionally, CLDN18.2, a cancer-associated gastric-lineage marker, has been targeted for precision therapy and molecular imaging in gastrointestinal tumors. Preclinical studies have shown that an mRNA-encoded anti-CLDN18.2 antibody displays stable pharmacokinetics and cytotoxicity comparable to recombinant protein. A prediction model for occult peritoneal metastasis in advanced gastric cancer has also been established, with CLDN18.2 score identified as an independent risk factor. Overall, CLDN18 has potential applications in ADC therapy, precision therapy, molecular imaging, and prediction models for certain types of tumors.

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    Customer Reviews

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    FAQ

    chat Cameron Jones (Verified Customer)

    What is the impact of CLDN18 loss in gastric cancer? Nov 14 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Loss of CLDN18 in the stomach can lead to severe atrophy, glandular dysplasia, and rapid progression to intraepithelial neoplasia, highlighting its critical role in gastric epithelial integrity and cancer progression. Nov 14 2020

    chat Jordan Davis (Verified Customer)

    How does CLDN18 expression influence the prognosis of gastric and gastroesophageal cancers? Jul 21 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CLDN18 is frequently expressed in gastric and gastro-oesophageal cancers, and its heterogeneity may have prognostic significance, warranting further investigation for clinical implementation. Jul 21 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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