Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. CCR8
  3. mProX™ Human CCR8 Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP GPCR Cell Lines,Drug Discovery Tools
    Family stable cell lines Chemokine Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human CCR8 Stable Cell Line

    [CAT#: S01YF-0923-PY41]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Protein
    CCR8
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    5637;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Infectious Research;Cardiovascular Research
    Related Diseases
    Molluscum Contagiosum;Kaposi Sarcoma
    Gene ID
    Human: 1237
    UniProt ID
    Human: P51685

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CCR8, known as the C-C chemokine receptor type 8, is another protein that has garnered attention in the scientific community. This receptor has been identified as playing a significant role in the function of regulatory T cells (Tregs) within tumor tissues. One of the groundbreaking studies in this domain highlighted the potential of CCR8-targeted therapy to deplete tumor-promoting Tregs, thereby eliciting potent antitumor immunity. Furthermore, the CCR8 receptor has been associated with the immunosuppressive environment in lung cancer, emphasizing its role in cytotoxic T lymphocyte suppression. Another study revealed the significance of CCR8+ Tregs in immunosuppression in lung cancer, suggesting the potential value of CCR8-targeted therapy for cancer treatment. Given these findings, CCR8 emerges as a potential therapeutic target in oncology, particularly in understanding tumor immunity and developing targeted interventions.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CCR8 Stable Cell Line (S01YF-0923-PY41). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Michelle (Verified Customer)

    How does the chemokine CCL18 interact with its receptor CCR8 in human microglial cells? Jul 18 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CCL18 may exhibit anti-inflammatory activity and activate the phagocytic function of microglia, playing a role in neural development, homeostasis, and repair mechanisms. Jul 18 2020

    chat Christopher (Verified Customer)

    What are the implications of GB2101, an anti-CCR8 antibody, in cancer treatment? Jul 27 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GB2101 is a novel monoclonal antibody that binds specifically to CCR8 with high affinity. It effectively blocks the CCL1-CCR8 pathway and suppresses tumor growth in vivo, making it a promising preclinical candidate for treating various tumor types. Jul 27 2021

    Related Products by Target
    • Human CCR8 Membrane Protein Lentiviral Expression Plasmid (CAT#: S01YF-1124-KX816)
    • Human CCR8 Membrane Protein Yeast Expression Plasmid (CAT#: S01YF-1124-KX586)
    • Human CCR8 Membrane Protein Insect Expression Plasmid (CAT#: S01YF-1124-KX471)
    • Human CCR8 Membrane Protein LNP Encapsulation mRNA (CAT#: S01YF-1124-KX241)
    • Human CCR8 Membrane Protein Mammalian Transient Expression Plasmid (CAT#: S01YF-1124-KX356)
    • mProX™ Human CCR8 Stable Cell Line (CAT#: S01YF-0923-PY41)
    • Human CCR8 Membrane Protein Lentivirus (CAT#: S01YF-1124-KX11)
    • Human CCR8 Membrane Protein In Vitro Transcription (IVT) mRNA (CAT#: S01YF-1124-KX126)
    • Human CCR8 Membrane Protein Bacterial Expression Plasmid (CAT#: S01YF-1124-KX701)
    • Human CCR8 Membrane Protein Retroviral Expression Plasmid (CAT#: S01YF-1124-KX931)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare