mProX™ Human CCR7 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Knockdown of CCR7 inhibits CCL19-induced migration and invasion.
Suppressing CCR7 had a notable impact on breast cancer cell migration triggered by CCL19. Our findings, derived from three autonomous experiments, demonstrate significant alterations in cell behavior. *P < 0.05 (vs. control), #P < 0.05 (vs. CCL19).
Ref: Xu, Bing, et al. "CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway." Cancer medicine 6.5 (2017): 1062-1071.
Pubmed: 28378417
DOI: 10.1002/cam4.1039
Research Highlights
Zacharias ZR, Houtman JCD. "OMIP-099: 31-color spectral flow cytometry panel to investigate the steady-state ." Cytometry. Part A : the journal of the International Society for Analytical , 2023.
A 31-color panel has been developed to define the steady-state phenotype of T cells in human peripheral blood, as shown in Table 1. This panel has been optimized using cryopreserved peripheral blood mononuclear cells (PBMC). The selected markers for this panel (CD45RA, CD45RO, CCR7, CD95) aim to characterize the steady-state phenotype of T cells and distinguish the main subsets (e.g., naive, T(EM) , T(CM) , T(EMRA) , T(SCM) ) of CD4, CD8, and gammadelta T cells. In addition, this panel includes markers to identify differentiation status (CD27, CD28), activation/antigen experience status (CD11a, CD49d, CD38, HLA-DR, CD56, and CD39), co-inhibitory marker expression (PD-1, TIM-3), and CD4 T helper subsets (CXCR3, CXCR5, CCR4, CCR6, Foxp3, CD25, and CD127). Overall, this optimized panel offers a comprehensive evaluation of the steady-state phenotype of human T cells.
Pubmed:
37814476
DOI:
10.1002/cyto.a.24799
Roger L, et al. "T cell memory revisited using single telomere length analysis.." Frontiers in immunology, 2023.
The authors of this study aimed to gain a better understanding of the underlying mechanisms of T cell memory. While it is known that antigen stimulation leads to clonal proliferation and differentiation, the relationship between cellular phenotype, replicative history, and longevity, which is crucial for long-lasting memory, has remained unclear. The researchers used established markers of differentiation to isolate different subsets of CD8(+) memory T cells and measure telomere lengths through a highly sensitive technique called single telomere length analysis. Naive cells were excluded based on their expression of CCR7 and CD45RA. The results showed that T cell memory differentiation may not follow a linear process as traditionally thought, with subsets expressing CD45RA having longer telomeres and therefore potentially longer longevity. These findings suggest a disconnect between replicative history and T cell memory differentiation.
Pubmed:
37781376
DOI:
10.3389/fimmu.2023.1100535
