mProX™ Human CCR6 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CCR6, known as the C-C chemokine receptor type 6, is another protein that has garnered attention in the scientific community. This receptor is known for its interaction with the ligand CCL20, forming the CCL20-CCR6 axis, which has been implicated in various pathological processes. For instance, the CCL20-CCR6 axis has been identified as playing a pivotal role in the progression of diseases like psoriasis and psoriatic arthritis. Moreover, research has highlighted the significance of the CCL20-CCR6 axis in endometriosis, where it mediates macrophages to promote the proliferation and migration of endometrial stromal cells by blocking autophagic flux. Additionally, the CCL20-CCR6 axis has been associated with cancer progression, emphasizing its potential as a therapeutic target. In the context of COVID-19, enrichment of CCR6+CD8+ T cells and CCL20 has been observed in the lungs of mechanically ventilated patients, suggesting a potential role in the disease's pathogenesis. Overall, the application of CCR6 in scientific research provides valuable insights into various physiological and pathological processes, from autoimmune diseases to cancer progression.