mProX™ Human CCR5 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CCR5, or C-C chemokine receptor type 5, is a protein that has been at the epicenter of numerous scientific investigations. This receptor is primarily recognized for its role in HIV-1 infection, as it serves as a co-receptor for the virus. One of the groundbreaking studies in this domain was the use of stem cells from a donor who was homozygous for CCR5 delta32, which led to long-term control of HIV in a patient, suggesting the potential for a functional cure. Furthermore, the CCR5-CCL axis has been identified as playing a crucial role in the remodeling of periodontal tissues, indicating its significance in orthodontic biophysical force application. Additionally, the CCL5/CCR5 axis has been linked to cancer progression, particularly in the context of prostate cancer, where it has been associated with proliferation, metastasis, angiogenesis, and drug resistance. The potential therapeutic repositioning of CCR5 inhibitors, such as Maraviroc, has also been explored for its immunomodulatory properties and potential co-analgesic effects in neuropathic pain therapy. In essence, the application of CCR5 in scientific research spans from infectious diseases to oncology, offering a plethora of avenues for therapeutic interventions.