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    mProX™ Human CCR3 Stable Cell Line

    [CAT#: S01YF-0923-PY36]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    CCR3
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    DU145;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Aids Dementia Complex;Esophagitis
    Gene ID
    Human: 1232
    UniProt ID
    Human: P51677

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CCR3, known as the C-C chemokine receptor type 3, is a protein that has been a focal point in numerous scientific studies. This receptor is recognized for its interaction with specific ligands, which play integral roles in various physiological processes. One of the significant findings related to CCR3 is its involvement in eosinophilic inflammation and the Th2 immune response. For instance, research has shown that gene knockdown of CCR3 can reduce eosinophilic inflammation, potentially due to the inhibition of the PI3K/AKT pathway. Another study highlighted the importance of the CCL5-CCR3 axis in breast cancer, suggesting its contribution to a worse prognosis in breast cancer patients. Furthermore, the CCR3 receptor has been linked to the modulation of neuropathic pain, indicating its potential as a therapeutic target. Given these findings, CCR3 emerges as a pivotal receptor in understanding various physiological and pathological processes, from inflammation to cancer progression.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CCR3 Stable Cell Line (S01YF-0923-PY36). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Karen (Verified Customer)

    How is CCR3 expression maintained in stabilized cell lines? Dec 25 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CCR3 expression can be maintained using specific growth conditions, inducible promoters, or other molecular techniques. It's essential to regularly validate its expression to ensure consistency in research. Dec 25 2022

    chat Rebecca (Verified Customer)

    Are there any specific antibodies available for CCR3 detection in cell lines? Jul 10 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, there are specific monoclonal antibodies like C3Mab-2 that can recognize endogenous CCR3 in certain cell lines and are suitable for immunocytochemistry. Jul 10 2022

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