mProX™ Human CCR1 Stable Cell Line

Product Information

Target Protein

CCR1

Target Family

Chemokine Family

Target Protein Species

Human

Host Cell Type

MKN28;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Autoimmune Research

Related Diseases

Behcet Syndrome;Mesangial Proliferative Glomerulonephritis

Gene ID

Human: 1230

UniProt ID

Human: P32246

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CCR1, or C-C chemokine receptor type 1, is another protein that has garnered attention in the scientific community. This receptor is known to bind to various ligands, including chemokines, which are small proteins involved in immune responses. The research indicates that CCR1 plays a pivotal role in mediating cellular responses, especially in the context of inflammation and immune cell migration. For instance, one study highlighted the potential of CCR1 antagonists as a treatment option for multiple myeloma. Another research article emphasized the role of CCR1 in the crosstalk between different cell types at the maternal-fetal interface, suggesting its involvement in pregnancy-related conditions. Moreover, the CCR1-CCR5 axis has been identified as a crucial immunological hub activated by tumor-derived factors. Given its involvement in various physiological and pathological processes, CCR1 presents itself as a potential therapeutic target in a range of diseases, from inflammatory disorders to cancers. In essence, the application of CCR1 in scientific research offers a window into understanding complex cellular interactions and developing targeted therapies.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Thomas (Verified Customer)

What is the primary function of CCR1 in cells? Jul 30 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

CCR1 is a chemokine receptor involved in the signaling of immune cells. It plays a role in the migration and activation of these cells during immune responses. Jul 30 2021

chat Joseph (Verified Customer)

Are there any diseases or conditions associated with CCR1 malfunction? Oct 26 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Abnormalities in CCR1 function or expression can be linked to immune-related diseases and certain types of cancers. It's essential to refer to specific research articles for detailed information. Oct 26 2021

Published Data

Fig.1 In vitro transwell assays confirmed that knockdown of CCR1 receptor abolished SOX18-mediated GC metastasis.

Transwell assays conducted in a controlled laboratory setting verified that the suppression of the CCR1 receptor negated the effects of SOX18 in driving GC metastasis.

Ref: Chen, Jie, et al. "SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7." Oncogene 39.33 (2020): 5536-5552.

Pubmed: 32616889

DOI: 10.1038/s41388-020-1378-1

Research Highlights

Xiong J, et al. "GPCR signaling contributes to immune characteristics of microenvironment and ." Science bulletin, 2023.
The Epstein-Barr virus (EBV) has been recognized as a primary cause of various cancers, yet the precise mechanism behind its interaction with the immune system during disease progression remains unclear. This study provides a comprehensive analysis of natural killer/T-cell lymphoma (NKTCL), a model disease to study EBV-related lymphomagenesis, through a variety of genomic, transcriptomic, and proteomic techniques. Results revealed a correlation between EBV gene patterns and oncogenic immune signaling, as well as distinct immune profiles within the tumor microenvironment based on single-cell transcriptome analysis. Additionally, a G-protein coupled receptor (GPCR) interactome reprogramming, likely induced by EBV interaction with transcriptional factors, was identified as a key factor in malignant progression. Targeting the chemokine receptor-1 (CCR1) showed promising results in NKTCL organoids, demonstrating its potential as a specific anti-cancer treatment against EBV. Overall, this study sheds light on the intricate relationship between EBV and cancer and provides potential therapeutic targets for EBV-related cancers.
Pubmed: 37798178 DOI: 10.1016/j.scib.2023.09.029

Chu YT, et al. "Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological ." Biomedicines, 2023.
The researchers found that CCR5 is associated with TH1 responses, while CCR1 is linked to TH1-like responses. Additionally, CCR4 in basophils and CCR3 in eosinophils are involved in TH2 and TH9 responses, respectively. CCR10 is associated with TH22 responses, while CCR6 is involved in TH17 responses. CXCR3 is linked to THalphabeta responses, while CCR8 is associated with regulatory T cells (Treg), and CCR2 is involved in TH3 responses. These findings help identify biomarkers for immune cells and provide insights into host immunological pathways. Understanding the chemokine and Toll-like receptor system is crucial for comprehending the function of the innate immune system, as well as adaptive immune responses.
Pubmed: 37760825 DOI: 10.3390/biomedicines11092384