mProX™ Human ADRB2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ADRB2 gene, encoding the beta-2 adrenergic receptor, has been a focal point in numerous scientific investigations due to its significant physiological implications. This receptor is known to play a vital role in the bronchial smooth muscle relaxation and vasodilation. Recent studies have highlighted the importance of ADRB2 in the context of cancer, where its expression was found to be significantly higher in brain metastases from cervical cancer, suggesting its potential role in metastatic processes. Additionally, research has shown that ADRB2 signaling is pivotal in mediating resistance to VEGFR2-TKIs, offering a promising combinatory approach to enhance the antitumor effect in non-small cell lung cancer. Furthermore, the activation of the ADRB2/PKA signaling pathway has been identified to enhance lipid synthesis in meibocytes, providing insights into potential therapeutic targets, especially in cases induced by beta-blocker glaucoma drugs. In summary, the ADRB2 gene has been recognized for its multifaceted applications in scientific research, spanning from respiratory health to cancer metastasis and lipid metabolism.