mProX™ Human ADRB2 Stable Cell Line

Product Information

Target Protein

ADRB2

Target Family

Adrenergic Family

Target Protein Species

Human

Host Cell Type

HGC-27;MGC-803;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Immunology Research

Related Diseases

Nocturnal Asthma;Status Asthmaticus

Gene ID

Human: 154

UniProt ID

Human: P07550

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ADRB2 gene, encoding the beta-2 adrenergic receptor, has been a focal point in numerous scientific investigations due to its significant physiological implications. This receptor is known to play a vital role in the bronchial smooth muscle relaxation and vasodilation. Recent studies have highlighted the importance of ADRB2 in the context of cancer, where its expression was found to be significantly higher in brain metastases from cervical cancer, suggesting its potential role in metastatic processes. Additionally, research has shown that ADRB2 signaling is pivotal in mediating resistance to VEGFR2-TKIs, offering a promising combinatory approach to enhance the antitumor effect in non-small cell lung cancer. Furthermore, the activation of the ADRB2/PKA signaling pathway has been identified to enhance lipid synthesis in meibocytes, providing insights into potential therapeutic targets, especially in cases induced by beta-blocker glaucoma drugs. In summary, the ADRB2 gene has been recognized for its multifaceted applications in scientific research, spanning from respiratory health to cancer metastasis and lipid metabolism.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Thomas (Verified Customer)

What is the role of ADRB2 in lung adenocarcinoma? Mar 08 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

ADRB2 is involved in the immune response and has been positively correlated with the infiltration level of most immune cells in lung adenocarcinoma. It may serve as a significant prognostic biomarker and a potential drug target. Mar 08 2020

chat Matthew (Verified Customer)

How does ADRB2 influence the tumor immune microenvironment in breast cancer? Jul 14 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

ADRB2 acts as a potential protective gene in breast cancer and plays a vital role in regulating immune responses. Jul 14 2021

Published Data

Fig.1 Effect of β-adrenergic signalling on the proliferation of GC cells in vitro

Silencing ADRB2 gene expression and subsequent assessment using CCK8 assay to confirm the impact of diverse ADRB agonists on gastric cancer cell proliferation.

Ref: Zhang, X., et al. "Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2. Cell Death Dis. 2019; 10 (11): 788."

Pubmed: 31624248

DOI: 10.1038/s41419-019-2030-2

Research Highlights

Mhatre I, et al. "Functional mutation, splice, distribution, and divergence analysis of impactful ." Scientific reports, 2023.
In this study, the researchers aimed to identify key genes associated with cardiovascular disease (CVD), particularly heart failure (HF), and understand their role in the disease. A cohort of 35 consented patients was sequenced to generate whole genome sequence (WGS) data. Functional mutation, splice, variant distribution, and divergence analysis were then performed to investigate the relationship between each type of mutation and its impact. The results showed that FLNA, CST3, LGALS3, and HBA1 were linked to enrichment pathways and genes like ACE, MME, LGALS3, NR3C2, PIK3C2A, CALD1, TEK, and TRPV1 were potentially significant. Furthermore, intron, 5' Flank, 3' UTR, and 3' Flank mutations were found to be the most common, while missense mutations had a higher functional impact. Based on their divergence analysis, the researchers concluded that HBA1, FADD, NPPC, ADRB2, ADBR1, MYH6, and PLN were consequential genes in CVD and HF.
Pubmed: 37798313 DOI: 10.1038/s41598-023-44127-1

Wang K, et al. "Human engineered cardiac tissue model of hypertrophic cardiomyopathy ." Frontiers in bioengineering and biotechnology, 2023.
The development of patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) provides a unique opportunity to study the relationship between genotype and phenotype in hypertrophic cardiomyopathy (HCM), a commonly inherited cardiac disease.
Pubmed: 37771571 DOI: 10.3389/fbioe.2023.1227184