mProX™ Human ADORA1 Stable Cell Line

Product Information

Target Protein

ADORA1

Target Family

Adenosine Family

Target Protein Species

Human

Host Cell Type

A375;SK-MEL-28;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cardiovascular Research

Related Diseases

Ischemia;Congestive Heart Failure.

Gene ID

Human: 134

UniProt ID

Human: P30542

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Adenosine receptor A1 (ADORA1) is a significant component in the realm of scientific research, particularly in the context of neurology and oncology. One of the notable findings is its link to early-onset Parkinson's disease, where a mutation in ADORA1 is associated with dysfunction in adenosine receptor heteromerization, potentially leading to a hyperglutamatergic state. Additionally, in the field of oncology, ADORA1 has been implicated in hepatocellular carcinoma (HCC). The recruitment of plasmacytoid dendritic cells, influenced by ADORA1 signaling, has been shown to induce immunosuppression in HCC. Targeting this recruitment could serve as a potential adjuvant strategy for immunotherapies in HCC. Furthermore, ADORA1's role in tumor immune evasion has been explored, where its inhibition can promote the effects of certain treatments in melanoma and NSCLC xenografts source. These findings underscore the importance of ADORA1 in various pathological conditions and its potential as a therapeutic target.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human ADORA1 Stable Cell Line (S01YF-0923-PY1). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Charles (Verified Customer)

What is the significance of ADORA1 in stabilized cell line research? Jan 02 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

ADORA1 plays a crucial role in various cellular processes and has been the subject of numerous studies to understand its function and potential applications in research. Jan 02 2023

chat Brian (Verified Customer)

Are there any known challenges or misconceptions related to ADORA1 stabilized cell lines? Mar 10 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

While ADORA1 stabilized cell lines offer valuable insights, it's essential to ensure the accuracy of the stabilization process to maintain the integrity of the research findings. Mar 10 2022

mProX™ Human ADORA1 Stable Cell Line

Made to Order Inquiry

Product Information

Product Properties

Protocols

Customer Reviews

Related Products by Target