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  • mProX™ Human ACKR3 Stable Cell Line

    [CAT#: S01YF-0923-PY50]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Protein
    ACKR3
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    Huh-7;SNU387;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Oculomotor-Abducens Synkinesis;Whim Syndrome 1
    Gene ID
    Human: 57007
    UniProt ID
    Human: P25106

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    ACKR3, also known as Atypical Chemokine Receptor 3, has been the subject of extensive research due to its diverse roles in various physiological processes. One of the significant findings related to ACKR3 is its role in platelet activation and ischemia-reperfusion tissue injury. Research has shown that ACKR3 acts as a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Additionally, ACKR3 has been identified to play a role in atherosclerosis. It has been demonstrated that arterial endothelial deficiency of ACKR3 attenuates atherosclerosis due to diminished arterial adhesion and invasion of immune cells. Another area of interest is the potential therapeutic applications of ACKR3. Studies have shown that targeting ACKR3 can lead to the selective elimination of senescent fibroblasts, which has implications in anti-aging and cancer therapies. In conclusion, ACKR3 is emerging as a key molecule in various research areas, from cardiovascular diseases to cancer, making it a potential target for future therapeutic strategies.

    Protocols

    Please visit our protocols page.

    Customer Reviews

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    FAQ

    chat Brian (Verified Customer)

    What role does ACKR3 play in atherosclerosis? Dec 06 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ACKR3 is involved in promoting atherosclerosis by mediating the adhesion of immune cells to arterial endothelium, likely through inflammatory MAPK and NF-kB pathways. Dec 06 2022

    chat Sharon (Verified Customer)

    How does BMP2 influence osteogenic differentiation through ACKR3? May 08 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    BMP2 drives the transduction of mesenchymal stem cells (MSCs) to the osteoblast lineage via the ACKR3/p38/MAPK signaling pathway. May 08 2022
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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