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    mProX™ Human ACKR1 Stable Cell Line

    [CAT#: S01YF-0923-PY52]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    ACKR1
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research;Digestive and Renal Research
    Related Diseases
    White Blood Cell Count Quantitative Trait Locus 1;Malaria
    Gene ID
    Human: 2532
    UniProt ID
    Human: Q16570

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Duffy Antigen Receptor for Chemokines (DARC/ACKR1) has been recognized for its potential as a biomarker in various medical fields. Its role in the immune system's defense against tumorigenesis and progression is particularly noteworthy. The receptor binds and internalizes chemokines, maintaining homeostatic levels and modulating leukocyte trafficking. A negative DARC status, prevalent among individuals of West African genetic ancestry, has been associated with a higher risk of developing breast cancer at a younger age. Additionally, the expression of ACKR1 in the erythroid compartment has been linked to the development of kidney disease. In the context of neuroinflammation, ACKR1 has been shown to favor transcellular T-cell diapedesis across the blood-brain barrier. These findings emphasize the multifaceted role of ACKR1 in immunology, oncology, and neurology, highlighting its importance in scientific research.

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    FAQ

    chat Karen (Verified Customer)

    What is the association of DARC/ACKR1 expression with breast tumors? Mar 27 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    DARC/ACKR1 expression is associated with immune landscape changes among triple-negative breast tumors and shows a correlation with tumor-associated leukocyte abundance. Mar 27 2023

    chat Sandra (Verified Customer)

    What role does endothelial ACKR1 play in breast cancer metastasis? Sep 12 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    It is hypothesized that endothelial ACKR1 promotes metastasis via retention of CXCL2 at endothelial cell junctions, increasing tumor cell chemotaxis and extravasation in triple-negative breast cancer metastasis. Sep 12 2021

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    • mProX™ Human ACKR1 Stable Cell Line (CAT#: S01YF-0923-PY52)
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