Human IGF1R Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX294]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein mRNA
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order LNP-mRNA encoding human IGF1R.
Target Protein
IGF1R
Target Protein Species
Human
Target Classificationp
Kinases/Enzyme
Target Research Area
Metabolic Research
Related Diseases
Insulin-Like Growth Factor I; Nk-Cell Enteropathy
Target Family
Kinases/Enzyme
RNA Type
LNP-mRNA
Nucleoside Modification Method
m1Ψ; m5C or specific requirements
Cap
Cap 0; Cap 1 or specific requirements
PolyA Tail (nt)
30 nt; 80 nt; 120 nt or specific requirements
5' UTR
Human globin alpha; 5' UTR seq can be modified according to the specific requirements
Promoter
T7
Tag
Based on specific requirements
Fluorescent Markers
Based on specific requirements
Formation
LNP Encapsulation mRNA
LNP Formulation
Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
Buffer
Tris buffer or PBS
Quality Control
OD260/280 (~1.90-2.50)
PASS
Agarose Gel Mobility
PASS
Sequence and Enzyme Digestion
PASS
Encapsulation Efficiency
PASS
mRNA Transfection Efficiency
PASS
Product Properties
Application
Drug discovery research and pre-clinical studies
Shipping
Blue Ice
Storage
Aliquot and store at 2-8°C for long term.
Target
Full Name
Insulin like growth factor 1 receptor
Introduction
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
IGF1R; IGFR; CD221; IGFIR; JTK13; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; Insulin like growth factor 1 receptor
Gene ID
UniProt ID
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