Neuropeptide FF Family Related Drug Discovery Products
Creative Biolabs has the assays you can rely on for high throughput screening, lead optimization, characterizing and discovering targets, and uncovering the complexity of disease pathways. We can offer membrane protein in vitro assay kits that save valuable laboratory time and is ideal for high throughput screening.
Membrane protein stable cell lines are widely used in many areas of biomedical research. Creative Biolabs can offer membrane protein stable cell lines to stablish in vitro models for High Throughput Screening.
Creative Biolabs offers high-quality, innovative tools to help research groups accelerate membrane protein drug discovery. They can be found by targets. If there is no product that meets your needs, please contact us.
The RFamide peptide family, which includes neuropeptide FF, contains proteins found in the Brain and peripheral tissues of many mammalian species, including humans. Emerging research has revealed that NPFF may be equally important in the central processing of visceral autonomic signals related to feeding, generation of central cardiovascular responses, stress, and neuroendocrine regulation. The neuropeptide's ability to modulate the antinociceptive effects of opioids was what initially sparked interest in it.
Fig.1 Members of the mammalian RFamide family. (Jhamandas, 2013)
Creative Biolabs offers a range of neuropeptide FF family drug discovery assays and products to contribute to the success of drug discovery:
Overview of Neuropeptide FF Family
The Npffr1 receptor, which has a high affinity for the avian peptide LPLRFamide, is the potential receptor for the NPVF, NPSF, hRPRF1 and hRPRF2 peptides. The expression of Npffr1 mRNA in rat and human tissues has been studied. Npffr1 is mostly expressed in neural tissues and is only weakly expressed in the periphery, which is a recurring pattern in those investigations. The eye, rat ovaries and testicles, as well as the pituitary gland in both humans and rats, are notable peripheral organs that express Npffr1. The spinal cord was shown to have the greatest Npffr1 mRNA expression in the human CNS. The amygdala and hippocampus in the human brain also showed substantial Npffr1 mRNA expression.
Npffr2 binds NPFF and NPAF. In the rat, mouse, and human, the tissue distribution of Npffr2 mRNA has been investigated. The placenta in humans has the highest level of Npffr2 mRNA expression. Apart for the white adipose tissue, pituitary gland, and heart, none of the other human peripheral tissues under investigation exhibit Npffr2 mRNA expression. Npffr2 mRNA is mostly expressed in the central nervous system (CNS) of rodents, while expression levels in peripheral tissues are often modest. The pituitary gland, eye, heart, kidney, and salivary gland described in the rat, and white adipose tissue macrophages (ATMs) recorded in the mouse, are examples of these peripheral tissues.
Neuropeptide FF Family Drug Discovery
Many physiological and behavioral processes, such as nociception, locomotion, reproduction, energy homeostasis, and reactions to pain and stress, are influenced by the wide family of neurotransmitters known as RFamide peptides, suggesting a significant therapeutic potential. The brain's ability to regulate neurohormones and sympathetic outflow is significantly influenced by NPFF. It is now possible to pinpoint the precise function and significance of these receptors in both physiological function and pathophysiological states like hypertension thanks to advancements in the identification and pharmacology of NPFF receptors as well as the availability of new and targeted antagonists. Compounds that target NPFF receptors may be used as therapeutic treatments to treat autonomic diseases like hypertension.
Reference
- Jhamandas, J.H.; Goncharuk, V. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Frontiers in endocrinology. 2013, 4: 8.
