TLR7
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.
| Full Name | Toll like receptor 7 |
| Gene ID | Human: 51284 Mouse: 170743 Rat: 317468 Monkey: 574291 |
| UniProt ID | Human: Q9NYK1 Mouse: P58681 Rat: A5H2Z9 Monkey: B3Y653 |
| Alternative Names | TLR7; IMD74; TLR7-like; toll-like receptor 7; toll-like receptor 7-like; Toll like receptor 7 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR7 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR7 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR7 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;PANC-1
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR7 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
